Diet-induced obese mice exhibit altered immune responses to early Salmonella Typhimurium oral infection

The Journal of Microbiology
Ricardo Ernesto Ramírez-OrozcoSergio López Briones

Abstract

Obesity is a chronic disease associated with different metabolic diseases as well as alterations in immune cell function. It is characterized by a chronic systemic low grade inflammation. There are several studies demonstrating the influence of obesity on the impaired immune response to infection. However, it is not completely clear whether the obese environment influences the development or maintenance of the immune response against infections. The aim of this study was to determine how obesity induced by a high-fat diet affects the immune response to an early oral Salmonella infection. Four groups of mice were kept in separate cages. Two of these designated as controls, fed with a normal diet; whereas other two groups were fed with a high fat diet for 10 weeks. Some mice were used for Salmonella oral infection. After 7 days of oral infection with S. Thypimurium the proportions of spleen cell subsets expressing activation markers in normal diet and HFD obese mice were stained with monoclonal antibodies and analyzed by flow cytometry. Also, mRNA levels of different cytokines were quantified by RT-PCR. It was found that obesity affects the function of the immune system against an early oral Salmonella infection, decreasing NK ce...Continue Reading

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Citations

Jun 11, 2020·Annual Review of Nutrition·Samuel Philip NobsEran Elinav
Apr 2, 2020·Frontiers in Immunology·Ina BährHeike Kielstein
Apr 4, 2021·Nutrients·Jian TanLaurence Macia

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