Diet-Induced Obesity Mice Execute Pulmonary Cell Apoptosis via Death Receptor and ER-Stress Pathways after E. coli Infection

Oxidative Medicine and Cellular Longevity
Fengyuan WangWentao Liu

Abstract

Obesity has developed into a considerable health problem in the whole world. Escherichia coli (E. coli) can cause nosocomial pneumonia and induce cell apoptosis during injury and infection. Normal (lean) and diet-induced obesity mice (DIO, fed with high-fat diet) were chosen to perform nasal instillation with E. coli to establish a nonfatal acute pneumonia model. At 0 h, 12 h, 24 h, and 72 h postinfection, lung tissues were obtained to measure cell apoptosis. As shown in this study, both lean and DIO mice exhibited histopathological lesions of acute pneumonia and increased cell apoptosis in the lung infected with E. coli. Interestingly, the relative mRNA and protein expressions associated with either endoplasmic reticulum stress or death receptor apoptotic pathway were all dramatically increased in the DIO mice after infection, while only significant upregulation of death receptor apoptotic pathway in the lean mice at 72 h. These results indicated that the DIO mice executed excess cell apoptosis in the nonfatal acute pneumonia induced by E. coli infection through endoplasmic reticulum stress and death receptor apoptotic pathway.

References

Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·G Matute-BelloT R Martin
Dec 30, 1999·American Journal of Respiratory Cell and Molecular Biology·J P MizgerdC M Doerschuk
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E AbrahamJ Arcaroli
Jan 4, 2001·The International Journal of Biochemistry & Cell Biology·I SchmitzP H Krammer
Sep 12, 2001·The International Journal of Biochemistry & Cell Biology·R K Barr, M A Bogoyevitch
Mar 26, 2003·Archives of Disease in Childhood·A M LiT F Fok
Nov 26, 2003·Cellular Signalling·Andrew Thorburn
Feb 18, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joseph P MizgerdEric S Silverman
Apr 21, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T LobsteinUNKNOWN IASO International Obesity TaskForce
Oct 12, 2004·FEBS Letters·Viviane Hoppe, Jürgen Hoppe
Mar 11, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hideaki KanetoYoshimitsu Yamasaki
Jun 16, 2005·Journal of Pediatric Hematology/oncology·Micha I BankBodil Laub Petersen
Jul 19, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Janet S LeeThomas R Martin
May 30, 2006·Biochemical and Biophysical Research Communications·Gagan Bajaj, Rajendra K Sharma
Sep 16, 2006·Cellular & Molecular Biology Letters·Jitka FaitovaBorivoj Vojtesek
Mar 8, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thomas A RussoRobert H Notter
Jun 27, 2007·Journal of Pharmaceutical Sciences·Tomris Ozben
Sep 27, 2007·Zoonoses and Public Health·R SuraR A French
Jan 15, 2008·American Journal of Respiratory Cell and Molecular Biology·Lee J QuintonJoseph P Mizgerd
Jul 1, 2008·Thorax·K M McCleanJ S Elborn
Jul 4, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·John KaravitisElizabeth J Kovacs
Aug 30, 2008·Molecular Pharmacology·Toru HosoiKoichiro Ozawa
Jun 6, 2009·Diabetes·Martina I LefterovaMitchell A Lazar
Oct 29, 2009·The Journal of Biological Chemistry·Chang-jiang HuangPeter C Butler
Dec 21, 2010·American Journal of Respiratory and Critical Care Medicine·Mitsuhiro YamadaClaire M Doerschuk
Mar 26, 2011·The European Respiratory Journal·I MoretR Menéndez
May 17, 2011·Biochemical and Biophysical Research Communications·Aki KashiwagiMasako Shimada
May 29, 2012·Biochemical and Biophysical Research Communications·Rajesh BhattacharjeeTimothy R Billiar
Sep 18, 2012·Journal of Applied Physiology·Ming ZhuStephanie A Shore
Mar 26, 2015·Methods in Molecular Biology·Aditya DandekarKezhong Zhang
Dec 27, 2016·Frontiers in Cellular and Infection Microbiology·Yongyong CuiXiangmei Zhou

❮ Previous
Next ❯

Software Mentioned

Pro Plus
Quantity One
image
SPSS

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis