Diet induced the change of mtDNA copy number and metabolism in Angus cattle

Journal of Animal Science and Biotechnology
Ying BaiJiuzhou Song

Abstract

Grass-fed and grain-fed Angus cattle differ in the diet regimes. However, the intricate mechanisms of different beef quality and other phenotypes induced by diet differences are still unclear. Diet affects mitochondrial function and dynamic behavior in response to changes in energy demand and supply. In this study, we examined the mtDNA copy number, mitochondria-related genes expression, and metabolic biomarkers in grass-fed and grain-fed Angus cattle. We found that the grass-fed group had a higher mtDNA copy number than the grain-fed group. Among different tissues, the mtDNA copy number was the highest in the liver than muscle, rumen, and spleen. Based on the transcriptome of the four tissues, a lower expression of mtDNA-encoded genes in the grass-fed group compared to the grain-fed group was discovered. For the mitochondria-related nuclear genes, however, most of them were significantly down-regulated in the muscle of the grass-fed group and up-regulated in the other three tissues. In which, COX6A2, POLG2, PPIF, DCN, and NDUFA12, involving in ATP synthesis, mitochondrial replication, transcription, and maintenance, might contribute to the alterations of mtDNA copy number and gene expression. Meanwhile, 40 and 23 metabolic bio...Continue Reading

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Citations

Aug 29, 2020·Journal of Animal Science and Biotechnology·Ying BaiJiuzhou Song
Aug 23, 2020·Antioxidants·Laura Bordoni, Rosita Gabbianelli
Jun 25, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura BordoniRobert A Olek

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Methods Mentioned

BETA
metabolomics profiling
PCR
RNA-seq

Software Mentioned

MetaboAnalyst
R
MUVR
Ensembl
Metabolon Laboratory Information Management System ( LIMS
Metabolon Platform
Hisat2

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