Diet Modulates the High Sensitivity to Systemic Infection in Newborn Preterm Pigs.

Frontiers in Immunology
Ole BækPer Torp Sangild

Abstract

Background: Preterm infants are born with an immature immune system, limited passive immunity, and are at risk of developing bacteremia and sepsis in the postnatal period. We hypothesized that enteral feeding, with or without added immunoglobulins, improves the clinical response to systemic infection by coagulase negative staphylococci. Methods: Using preterm cesarean delivered pigs as models for preterm infants, we infused live Staphylococcus epidermidis (SE, 5 × 109 colony forming units per kg) systemically 0-3 days after birth across five different experiments. SE infection responses were assessed following different gestational age at birth (preterm vs. term), enteral milk diets (bovine colostrum, infant formula with or without added porcine plasma) and with/without systemic immunoglobulins. Pigs infected with SE were assessed 12-48 h for clinical variables, blood bacteriology, chemistry, hematology, and gut dysfunction (intestinal permeability, necrotizing enterocolitis lesions). Results: Adverse clinical responses and increased mortality were observed in preterm vs. term pigs, when infected with SE just after birth. Feeding bovine colostrum just after birth improved blood SE clearance and clinical status (improved physica...Continue Reading

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Citations

Jun 12, 2021·Pediatric Research·Xiaoyu PanPer Torp Sangild
May 20, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shuqiang RenDuc Ninh Nguyen
Aug 28, 2021·Nutrients·Per Torp SangildDouglas G Burrin

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Methods Mentioned

BETA
cesarean section
biopsy
enzyme-linked immunosorbent assay
ELISA
flow cytometry

Software Mentioned

PigLWin
BD Accuri

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