Diet Supplementation in ω3 Polyunsaturated Fatty Acid Favors an Anti-Inflammatory Basal Environment in Mouse Adipose Tissue

Nutrients
Cecilia ColsonDidier F Pisani

Abstract

Oxylipins are metabolized from dietary ω3 and ω6 polyunsaturated fatty acids and are involved in an inflammatory response. Adipose tissue inflammatory background is a key factor of metabolic disorders and it is accepted that dietary fatty acids, in terms of quality and quantity, modulate oxylipin synthesis in this tissue. Moreover, it has been reported that diet supplementation in ω3 polyunsaturated fatty acids resolves some inflammatory situations. Thus, it is crucial to assess the influence of dietary polyunsaturated fatty acids on oxylipin synthesis and their impact on adipose tissue inflammation. To this end, mice fed an ω6- or ω3-enriched standard diet (ω6/ω3 ratio of 30 and 3.75, respectively) were analyzed for inflammatory phenotype and adipose tissue oxylipin content. Diet enrichment with an ω3 polyunsaturated fatty acid induced an increase in the oxylipins derived from ω6 linoleic acid, ω3 eicosapentaenoic, and ω3 docosahexaenoic acids in brown and white adipose tissues. Among these, the level of pro-resolving mediator intermediates, as well as anti-inflammatory metabolites, were augmented. Concomitantly, expressions of M2 macrophage markers were increased without affecting inflammatory cytokine contents. In vitro, the...Continue Reading

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Citations

Mar 11, 2020·International Journal of Molecular Sciences·Dmitry V ChistyakovMarina G Sergeeva
Sep 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Patrick MunroDidier F Pisani
Mar 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Javier Ávila-RománCristina Torres-Fuentes
May 8, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elisa Félix-SorianoMaría J Moreno-Aliaga
Jun 24, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ziye ZhuYanqi Dang
Nov 5, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ivan LiakhAdriana Mika

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Methods Mentioned

BETA
PCR

Software Mentioned

AxioVision
InStat
GraphPad

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