PMID: 8994306Nov 1, 1996Paper

Diet: the neglected variable in chemical safety evaluations

Toxicologic Pathology
P M Newberne, A V Sotnikov

Abstract

The objectives of this review are to alert the community of toxicologic pathologists to the types and significance of various diets fed to experimental animals used in safety evaluations of drugs and other chemicals, to acquaint investigators with dietary nutrients and contaminants of significance to research animals, to review some of the consequences of improper or inadequate diets on results of safety evaluations, and, finally, to offer a brief introduction to a highly promising new digital specimen technology for evaluating histopathology of tissues from animals used in safety evaluations with the aid of computers. Results that form the basis for this review have accumulated for more than 4 decades during research conducted during appointments at the University of Missouri, Columbia; Auburn University; Massachusetts Institute of Technology; and Boston University School of Medicine. The methods used in these studies have generally been state-of-the-art at the time the studies were conducted and involved an integration of techniques and methods used in fundamental nutrition, toxicology, and experimental pathology. Some of these investigations have shown that contaminants, naturally occurring and man-made, intentional and noni...Continue Reading

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Citations

Jul 3, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·K P KeenanR Dixit
Mar 1, 2009·Journal of Toxicologic Pathology·Robert R Maronpot
Aug 9, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Christopher P ChengelisHiroyuki Suzuki
Oct 24, 2013·BioMed Research International·Suja Rani SasidharanAmit Agarwal
Jan 22, 2013·Toxicologic Pathology·Kevin P KeenanWanda M Haschek

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