Diet with Low Molecular Weight Chitosan exerts neuromodulation in Rotenone induced Drosophila model of Parkinson's disease.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
P Pramod Kumar, Keelara V Harish Prashanth

Abstract

Rotenone (ROT) is well known pesticide been used in agriculture due to its low cost and rapid action. This has also been widely used to establish Parkinson's disease (PD) models in rodents. Here we have evaluated the role of well established potent molecule 'Low Molecular Weight Chitosan (LMWC)' against ROT induced neurotoxicity in Drosophila melanogaster. Male adult flies (8-10 days) were induced for neurotoxicity using ROT (500 μM) and treated with LMWC (5 & 10 mg/mL basal media) during 7 days experiment. Subsequently, neurodegenerative and behavioural parameters were assessed. As a result, flies exposed to ROT alone showed decreased locomotor behaviour in negative geotaxis and open-field studies and had a higher incidence of mortality compared to control group. These effects were accompanied by decrease in dopamine level, ETC complexes and increase in reactive oxygen species (ROS) production and cholinergic activities in head and body of the flies, suggesting ROT was able to induce oxidative stress. Co-exposure of LMWC reversed the ROT induced locomotor impairment, exploratory deficits and changes the biochemical parameters to normal level and increased the survival rate to 16 days. Thus, we suggested LMWC may be considered ...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B MannervikH Jörnvall
Jan 1, 1984·Methods in Enzymology·H Aebi
Mar 1, 1984·Analytical Biochemistry·R W Moreadith, G Fiskum
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S ShimizuY Tsujimoto
Jul 10, 2003·Trends in Neurosciences·Céline PerierSerge Przedborski
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana NavarroAlberto Boveris
Feb 18, 2005·Biochimica Et Biophysica Acta·K V Harish Prashanth, R N Tharanathan
Mar 10, 2005·The Journal of Biological Chemistry·Jason CallioCharleen T Chu
Sep 6, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jason R RichardsonGary W Miller
Dec 23, 2006·International Journal of Pharmaceutics·A DalpiazB Pavan
Mar 14, 2007·Journal of Pineal Research·Karuppagounder S SaravananKochupurackal P Mohanakumar
Mar 9, 2010·Toxicology and Industrial Health·Ibrahim Abdulwahid Arif, Haseeb Ahmad Khan
Jun 5, 2010·CNS & Neurological Disorders Drug Targets·Frank Hirth
Aug 18, 2010·Marine Drugs·Ratih Pangestuti, Se-Kwon Kim
Oct 5, 2010·Progress in Brain Research·Jason R Cannon, J Timothy Greenamyre
Apr 14, 2011·Bioorganic & Medicinal Chemistry Letters·Young-Sook ChoJae-Young Je
Dec 2, 2011·Indian Journal of Pharmaceutical Sciences·T AroraK K Sharma
Dec 4, 2012·The International Journal of Biochemistry & Cell Biology·Xuejin ZhangXuejun Zhang
Nov 2, 2013·Current Neuropharmacology·Mirjana B ColovićVesna M Vasić
Nov 26, 2015·International Journal of Biological Macromolecules·Shiliang JiaYaxuan Sun
May 22, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cláudia SaraivaLiliana Bernardino
Jan 7, 2017·Current Topics in Developmental Biology·V L Hewitt, A J Whitworth
Mar 17, 2017·Journal of Dietary Supplements·Yasser A KhadrawyEman N Hosny
Mar 15, 2018·Cell and Tissue Research·K J BillingsleyA B Singleton
Jun 19, 2018·International Journal of Nanomedicine·Ana Carolina Martínez-TorresCristina Rodríguez-Padilla
Sep 9, 2018·Biomaterials·Hannah B T MoranEd C Lavelle
Oct 28, 2018·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Shanda de Freitas CoutoMarina Prigol
Nov 9, 2018·Frontiers in Pharmacology·Bee Ling TanHeshu Sulaiman Rahman
Nov 15, 2018·Neurotoxicity Research·Venkatesan ManigandanGilles J Guillemin
Jan 30, 2019·International Journal of Biomaterials·Hari Sharan Adhikari, Paras Nath Yadav
Feb 5, 2019·Neuroscience Letters·Caner GünaydınS Sırrı Bilge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.