Dietary α-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones-Microbiota-Inflammation Axis in Rats.

Frontiers in Endocrinology
Ting WangHao Wang

Abstract

Polycystic ovary syndrome (PCOS) represents a common endocrine-metabolic disorder disease with chronic low-grade inflammation and alteration of intestinal flora. Serving as functional food, flaxseed oil (FO), which is rich in plant-derived α-linolenic acid of omega-3 polyunsaturated fatty acids, has been proven to benefit for chronic metabolic diseases. However, the exact role of dietary FO on PCOS remains largely unclear. In the present study, 6-week-old female Sprague-Dawley rats were randomly divided into four groups (eight rats/group), including (a) pair-fed (PF) control (CON) group (PF/CON), (b) FO-fed CON group (FO/CON), (c) PF with letrozole-induced PCOS model (MOD) group (PF/MOD), and (d) FO-fed MOD group (FO/MOD). All rats were fed a standard diet. After 3 weeks of modeling and subsequent 8 weeks of treatment, the rats in diverse groups were euthanized and associated indications were investigated. The results showed that dietary FO ameliorated the disorder of estrous cycle and ovarian morphology. In parallel, dietary FO improved the sex steroid hormone disturbance (luteinizing hormone/follicle-stimulating hormone, estrogen, testosterone, and progesterone), body weights, dyslipidemia, and insulin resistance. Moreover, F...Continue Reading

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Citations

Nov 3, 2020·Frontiers in Cellular and Infection Microbiology·Yumei ZhouZhuoxin Yang
May 1, 2021·International Journal of Molecular Sciences·Siarhei A DabravolskiAlexander N Orekhov
Aug 11, 2021·Nutrients·Małgorzata SzczukoLuciano Saso
Sep 24, 2021·Phytotherapy Research : PTR·Qianghua YuanLi Liu
Oct 16, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Akari KusamotoYutaka Osuga

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Datasets Mentioned

BETA
PRJNA624034

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR

Software Mentioned

SPSS
GraphPad
GraphPad Prism

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