Dietary accumulation, disposition, and metabolism of technical pentabrominated diphenyl ether (de-71) in pregnant mink (Mustela vison) and their offspring

Environmental Toxicology and Chemistry
Si ZhangJonathan W Martin

Abstract

Concentrations of polybrominated diphenyl ethers (PBDEs) in humans and wildlife suggest significant bioaccumulation potential in mammals, but no quantitative biomagnification data from controlled experiments are currently available. As part of a larger study examining the effects of PBDEs on mink (Mustela vison) reproduction and development, we examined congener-specific tissue distribution, maternal transfer, biotransformation, and biomagnification of the technical penta-BDE mixture, DE-71, in farmed mink. Adult female mink were fed one of four concentrations of DE-71 (0-2.5 microg/g) in the diet from breeding through gestation and until weaning at 6 weeks postparturition. Parent PBDEs were measured in tissues and excreta of adult mink, kits, and juveniles, whereas hydroxylated PBDEs (OH-PBDEs) were measured in juveniles only. Similar lipid-normalized concentrations of PBDEs were detected in most tissues of adult mink with the exception of brain, in which concentrations were significantly lower. Kits, however, had a higher proportion of PBDEs in brain compared with adults, presumably because of incomplete development of the blood-brain barrier. Maternal transfer favored lower-brominated PBDE congeners, and the bulk of the body...Continue Reading

Citations

Jan 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eleonora NapoliCecilia Giulivi
Mar 19, 2013·Environmental Health : a Global Access Science Source·Megan K HortonPam Factor-Litvak
Jan 28, 2011·Reviews on Environmental Health·Susan D ShawLinda S Birnbaum
Jul 22, 2014·Environmental Science and Pollution Research International·Li QinZunyao Wang
Mar 23, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Heather J Hamlin, Louis J Guillette
May 2, 2012·Toxicology and Applied Pharmacology·Crystal Y UsenkoErica D Bruce
Apr 6, 2021·Reproductive Toxicology·Xiaotong WangBernard Robaire

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