PMID: 9631960Jun 19, 1998Paper

Dietary additives and the acquisition of cocaine self-administration in rats

Psychopharmacology
M E Carroll, S T Lac

Abstract

The effects of dietary caffeine and the amount and palatability of food on the acquisition of cocaine (0.2 mg/kg) self-administration were examined. Using an autoshaping procedure, seven groups of 13 rats each were trained to press a lever resulting in a cocaine (0.2 mg/kg infusion under a fixed-ratio 1 (FR 1) schedule. One group had ad libitum access to caffeine- (0.2% w/w) admixed food. Three groups had access to 10 g, 20 g or ad lib food each day. Another three groups had the same three amounts of ground food with powdered saccharin (0.2% w/w) added. During daily 6-h autoshaping sessions, ten infusions were delivered each hour under a random-time 90-s schedule after a brief (15 s) extension of a retractable lever. These were followed by 6-h self-administration sessions, when the lever remained extended and cocaine infusions were available under an FR 1 schedule. The acquisition criterion was self-administration of a mean of 100 infusions over 5 days. Cocaine self-administration was accelerated in the caffeine group compared to the regular chow group. However, by 30 days nearly the same percentage of rats in the caffeine and regular food groups met the acquisition criterion. In the other six groups, as the amount of food incr...Continue Reading

Citations

Feb 23, 2011·Reviews in Endocrine & Metabolic Disorders·Emil EgeciogluSuzanne L Dickson
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·G Tanda, S R Goldberg
Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·W J LynchM E Carroll
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Andrew D MorganMarilyn E Carroll
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·M Loebens, H M T Barros
Mar 11, 2004·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Janet Audrain-McGovernE Paul Wileyto
Aug 11, 2010·Experimental and Clinical Psychopharmacology·Matthew W JohnsonRoland R Griffiths
Apr 14, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Angelica RochaJack R Nation
Jan 16, 2008·Genes, Brain, and Behavior·M Pravetoni, K Wickman
Apr 14, 2005·Learning & Behavior·David N Kearns, Stanley J Weiss
Jun 21, 2014·Psychopharmacology·Vassilis N Panagopoulos, Elizabeth Ralevski
Sep 4, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Petra SuchankovaElisabet Jerlhag
Jun 15, 2007·Substance Use & Misuse·David B Newlin, Kevin A Strubler
Feb 7, 2012·Frontiers in Neuroendocrinology·Johan AlsiöHelgi B Schiöth
Jan 1, 2008·Drug Discovery Today. Disease Models·Jasmine J Yap, Klaus A Miczek
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Margaret J MorrisR Frederick Westbrook
Sep 7, 2007·Regulatory Peptides·Paul J WellmanAudrea E Elliott
Dec 8, 2004·Regulatory Peptides·Paul J WellmanJack R Nation
Jan 3, 2006·Pharmacology, Biochemistry, and Behavior· Yajie Ding Lan Ma
Sep 4, 2007·Pharmacology, Biochemistry, and Behavior·Paul J WellmanKristina W Davis
Oct 21, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Casey E O'NeillRyan K Bachtell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.