Dietary alanyl-glutamine improves growth performance of weaned piglets through maintaining intestinal morphology and digestion-absorption function

Animal : an International Journal of Animal Bioscience
T D ZouJ M You

Abstract

Alanyl-glutamine (Ala-Gln), a highly soluble and stable glutamine dipeptide, is known to improve gut integrity and function. The aim of this study was to evaluate whether dietary Ala-Gln supplementation could improve growth performance, intestinal development and digestive-absorption function in weaned piglets. A total of 100 purebred Yorkshire piglets weaned at 21 days of age were assigned randomly to four dietary treatment groups and fed a basal diet (control group) or a basal diet containing 0.15%, 0.30% and 0.45% Ala-Gln, respectively. Compared with the control group, piglets fed the Ala-Gln diets had higher average daily gain and lower feed : gain and diarrhea rate (P < 0.05). Moreover, dietary Ala-Gln supplementation increased villous height and villous height : crypt depth ratio in duodenum and jejunum (P < 0.05), as well as the activities of maltase and lysozyme in jejunum mucosa (P < 0.05). In addition, a decrease in serum diamine oxidase activity and crypt depth in duodenum and jejunum was observed in piglets fed the Ala-Gln diets (P < 0.05). Serum cytosolic phospholipase A2 (cPLA2) concentration and gene expression of cPLA2, Na+-dependent glucose transporter 1, glucose transporter 2 and peptide transporter 1 in jejun...Continue Reading

References

Oct 1, 1996·The Journal of Nutrition·G WuD A Knabe
May 1, 2001·Seminars in Pediatric Surgery·D P O'BrienB W Warner
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 19, 2003·Current Infectious Disease Reports·Benedito A. Carneiro-FilhoRichard L. Guerrant
Mar 17, 2004·Burns : Journal of the International Society for Burn Injuries·Xi PengShiliang Wang
Aug 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K Khan, M Elia
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adam J MoeserAnthony T Blikslager
Oct 4, 2006·British Journal of Pharmacology·I DeyK Chadee
Feb 28, 2007·Journal of Pediatric Gastroenterology and Nutrition·Noélia L LimaAldo A M Lima
Nov 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Feli SmithAdam J Moeser
Jul 30, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Priscilla M UenoSean R Moore
Sep 21, 2013·The Journal of Nutrition·Ignacio R IpharraguerreDouglas G Burrin
Dec 20, 2013·Journal of Animal Science·J YinY L Yin
Mar 4, 2014·PloS One·Pia V RöderHannelore Daniel
Mar 21, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sean R MooreNoah F Shroyer
Apr 19, 2016·Nutrition Research Reviews·Warren M Miner-Williams, Paul J Moughan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.