Dietary alpha-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets

Amino Acids
Yongqing HouGuoyao Wu

Abstract

Neonates are at increased risk for inflammatory bowel disease, but effective prevention and treatments are currently limited. This study was conducted with the lipopolysaccharide (LPS)-challenged piglet model to determine the effects of dietary supplementation with alpha-ketoglutarate (AKG) on the intestinal morphology and function. Eighteen 24-day-old pigs (weaned at 21 days of age) were assigned randomly to control, LPS, and LPS + AKG groups. The piglets in the control and LPS groups were fed a corn- and soybean meal-based diet, whereas the LPS + AKG group was fed the basal diet supplemented with 1% AKG. On days 10, 12, 14, and 16, piglets in the LPS and LPS + AKG groups received intraperitoneal administration of LPS (80 microg/kg BW), whereas piglets in the control group received the same volume of saline. On day 16, D-xylose was orally administrated to all pigs at the dose of 0.1 g/kg BW, 2 h after LPS or saline injection, and blood samples were collected 3 h thereafter. Twenty-four hours post-administration of LPS or saline, pigs were killed to obtain intestinal mucosae for analysis. Compared with the control group, LPS challenge reduced (P < 0.05) protein levels, the ratio of villus height to crypt depth, and the ratio of...Continue Reading

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Citations

Sep 16, 2010·Amino Acids·Xilong LiGuoyao Wu
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Bi'e TanGuoyao Wu
Feb 18, 2016·Nutrition Reviews·Marie-Edith Arnal, Jean-Paul Lallès
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Dec 6, 2011·The Journal of Nutritional Biochemistry·Xiangfeng KongGuoyao Wu
Feb 5, 2011·Diabetes/metabolism Research and Reviews·Zhenping LiuKjeld Hermansen
Mar 29, 2016·Journal of Agricultural and Food Chemistry·Liuqin HeYulong Yin
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Mar 1, 2017·Journal of Agricultural and Food Chemistry·Liuqin HeYulong Yin
Jun 9, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Shuangshuang GuoBinying Ding
Apr 26, 2018·International Journal of Molecular Sciences·Dan YiGuoyao Wu
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