PMID: 6159838May 1, 1980Paper

Dietary alpha-linolenic acid and arterial pressure in the rat

Archives internationales de physiologie et de biochimie
J P BlondP Lemarchal

Abstract

The effect of dietary alpha-linolenic acid (18: 3 n-3) upon the arterial pressure of rats has been studied. Three experiments were carried out on rats of different ages that were fed a diet containing alpoha-linolenic acid in the form of Primor oil (rapeseed oil low in erucic acid). Control animals were fed a peanut oil diet and a third group of rats was fed a low-lipid, commercial diet. The arterial pressure of the rats was periodically measured. After a two- or three-month period (depending on the experiment), the rats were killed. Some of the livers were taken out and their fatty acids analysed. Comparing the results obtained in the rats fed on the alpha-linolenic acid diet with those of the control rats, we found that: (1) Dietary alpha-linolenic acid brought about no noticeable effect upon arterial pressure. (2) The arachidonic: linoleic (w/w) ratio in the liver lipids was lowered in the animals that had received alpha-linolenic acid, indicating a partial inhibition of the biosynthesis of arachidonic acid in these rats. Two hypotheses have been tentatively proposed to explain the absence of hypertensive effect following the administration of alpha-linolenic acid, in spite of its inhibitory effect upon the conversion of lin...Continue Reading

References

Jan 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·L A SAPIRSTEIND R DRURY

❮ Previous
Next ❯

Citations

Jan 1, 1984·Biochimica Et Biophysica Acta·L A Smets, W P Van Beek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.