Dietary alpha-tocopherol affects differential gene expression in rat testes

IUBMB Life
Cristina RotaGerald Rimbach

Abstract

Gene-chip technology was employed to study the effect of dietary vitamin E (VE) on gene expression in rat testes. Male albino rats were fed with either a diet deficient in VE or a standard diet containing VE. Differential gene expression was monitored at five individual time-points over a period of 14 months with all animals individually profiled. Low VE intake resulted in the consistent up-regulation of 7-dehydrocholesterol reductase and GATA binding protein 4, both involved in testosterone synthesis. Cyclin D3, important in cell cycle progression and Wilms tumor 1, related to cancer development, were also up-regulated in the vitamin E deficient animals. This study demonstrates that low dietary VE intake has long-term effects on gene expression in the testes. Our data provides insights into the possible molecular mechanisms underlying the beneficial effects of vitamin E on the male reproductive organ.

Citations

Jun 25, 2008·The British Journal of Nutrition·Siegfried KnasmüllerKarl-Heinz Wagner
Dec 1, 2006·Nutrition Research Reviews·Regina Brigelius-Flohé
Sep 27, 2008·FEBS Letters·Sonja GaedickeGerald Rimbach
Jan 10, 2009·Free Radical Biology & Medicine·Regina Brigelius-Flohé
Jun 15, 2007·Free Radical Biology & Medicine·Angelo Azzi
Mar 9, 2005·Annals of the New York Academy of Sciences·Luca BarellaGerald Rimbach
Dec 17, 2010·Chembiochem : a European Journal of Chemical Biology·Julien ChapelatWolf-D Woggon
Feb 26, 2010·Molecular Nutrition & Food Research·Patricia HuebbeGerald Rimbach
Jun 12, 2021·Annual Review of Nutrition·William S BlanerMaret G Traber

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