Dietary alpha-tocopherol prevents dehydroepiandrosterone-induced lipid peroxidation in rat liver microsomes and mitochondria

Toxicology Letters
J SwierczynskiD Mayer

Abstract

Dehydroepiandrosterone (DHEA), an adrenal steroid, causes lipid peroxidation in rat liver microsomes and mitochondria and induces hepatocarcinogenesis. It was investigated whether alpha-tocopherol, a naturally occurring free radical chain terminator, could decrease lipid peroxidation. When DHEA-free diet supplemented with increasing concentrations of alpha-tocopherol (25, 50, 100, 200, 400 and 1000 mg/kg diet) was fed to rats for 7 days, a marked lipid peroxidation (measured as thiobarbituric acid reactive substances formation) was observed at concentrations 25 and 50 mg/kg in liver microsomes and mitochondria isolated from these animals. Lipid peroxidation was significantly reduced at concentrations > or = 100 mg/kg. When DHEA (500 mg/kg diet) was fed to rats simultaneously with increasing concentrations of alpha-tocopherol, strong lipid peroxidation was observed at alpha-tocopherol concentrations < or = 200 mg/kg diet. However, microsomes and mitochondria isolated from livers of rats fed alpha-tocopherol at doses of 400 and 1000 mg/kg diet produced only negligible amounts of thiobarbituric acid reactive substances. The data show that high concentrations of alpha-tocopherol in the diet decrease DHEA-induced microsomal and mito...Continue Reading

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Citations

Dec 31, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Francisco CorreaEdmundo Chávez
May 22, 2003·Life Sciences·Raffaella MastrocolaGiuseppe Boccuzzi
Nov 9, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Długosz, D Piotrowska
Jul 13, 1999·Free Radical Biology & Medicine·M AragnoG Boccuzzi
Feb 26, 2011·Steroids·Matheus Parmegiani JahnLuiz Carlos Kucharski
Mar 6, 2012·Annals of Laboratory Medicine·Fazilet DuyguAbdullah Taskin
Mar 26, 2011·Radiation Research·Merriline M SatyamitraVenkataraman Srinivasan

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