Jul 1, 1976

Dietary and hormonal regulation of the content of acetyl coenzyme A carboxylase-synthesizing polysomes in rat liver

Proceedings of the National Academy of Sciences of the United States of America
S NakanishiS Numa

Abstract

Specific polysomes involved the the synthesis of acetyl-CoA carboxylase [acetyl-CoA: carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] have been identified by the binding of 125I-labeled antiacetyl-CoA carboxylase to rat liver polysomes. The binding is highly specific and occurs through the recognition of the nascent peptide chains on polysomes. With the use of the 125I-labeled antibody binding technique, it has been demonstrated that the relative content of acetyl-CoA carboxylase-synthesizing polysomes in the liver correlates well with the rate of hepatic synthesis of the enzyme in rats subjected to different dietary conditions as well as in alloxan-diabetic rats with or without insulin treatment.

Mentioned in this Paper

Hormone Regulation
Polyribosomes
Set of Polysomal Ribosomes
Diet
Acetyl Coenzyme A
Hepatic
Dioxide
Acetyl-CoA Carboxylase
Streptozotocin Diabetes
Antigen-Antibody Reactions

About this Paper

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