Dietary and lifestyle factors of DNA methylation

Methods in Molecular Biology
Unhee Lim, Min-Ae Song

Abstract

Lifestyle factors, such as diet, smoking, physical activity, and body weight management, are known to constitute the majority of cancer causes. Epigenetics has been widely proposed as a main mechanism that mediates the reversible effects of dietary and lifestyle factors on carcinogenesis. This chapter reviews human studies on potential dietary and lifestyle determinants of DNA methylation. Apart from a few prospective investigations and interventions of limited size and duration, evidence mostly comes from cross-sectional observational studies and supports some associations. Studies to date suggest that certain dietary components may alter genomic and gene-specific DNA methylation levels in systemic and target tissues, affecting genomic stability and transcription of tumor suppressors and oncogenes. Most data and supportive evidence exist for folate, a key nutritional factor in one-carbon metabolism that supplies the methyl units for DNA methylation. Other candidate bioactive food components include alcohol and other key nutritional factors of one-carbon metabolism, polyphenols and flavonoids in green tea, phytoestrogen, and lycopene. Some data also support a link of DNA methylation with physical activity and energy balance. Ef...Continue Reading

Citations

Oct 3, 2012·Environmental Health Perspectives·Bob Weinhold
Jan 8, 2014·BMC Genetics·Jaroslav Fulneček, Aleš Kovařík
Nov 29, 2013·Epigenomics·Susanne M HenningDavid Heber
Jun 5, 2013·Schizophrenia Bulletin·Jingyu LiuVince D Calhoun
Apr 25, 2012·Immunity & Ageing : I & a·Carmela R BalistreriGiuseppina Colonna-Romano
May 9, 2013·Climacteric : the Journal of the International Menopause Society·P Chedraui, F R Pérez-López
Oct 1, 2015·Journal of Crohn's & Colitis·Edel McDermottTherese M Murphy
Dec 9, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Maléne E LindholmCarl Johan Sundberg
Sep 5, 2015·BioMed Research International·Francesca Pacchierotti, Marcello Spanò
Apr 8, 2014·Journal of Neurogenetics·A GuidottiA Zhubi
Jan 28, 2015·Journal of Translational Medicine·Alina KurylowiczMonika Puzianowska-Kuznicka
Dec 10, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Salah AzziMarie-Aline Charles
Mar 26, 2015·Frontiers in Genetics·Jonathan A Heiss, Hermann Brenner
Jul 30, 2014·Frontiers in Aging Neuroscience·Kaushal SharmaAkshay Anand
Feb 18, 2015·Epigenomics·Andrey A ShabalinEdwin J C G van den Oord
Jan 12, 2017·Human Molecular Genetics·Konrad RawlikAlbert Tenesa
Nov 10, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N Meireles Da CostaL F Ribeiro-Pinto
Nov 23, 2016·Nature Reviews. Rheumatology·George C TsokosKathleen E Sullivan
Dec 23, 2016·International Journal of Cancer. Journal International Du Cancer·Jie ShenHua Zhao
Feb 2, 2017·Virus Research·Sérgio Menezes Amaro FilhoMiguel Angelo Martins Moreira
Apr 10, 2013·The Journal of International Medical Research·Ming LiJuying Zhou
Oct 13, 2017·Journal of Adolescent and Young Adult Oncology·Julia Ferrari Carneiro TeixeiraLuciana Pellegrini Pisani
Nov 22, 2016·Genetics & Epigenetics·Ana L Arellano-OrtizFlorinda Jiménez-Vega
May 3, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·H M McSwiggin, A M O'Doherty
Aug 12, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nicolas BrucatoClyde Francks
Oct 6, 2018·Clinical and Experimental Pharmacology & Physiology·Stefanie StangenbergSonia Saad
Oct 30, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Stephanie DiasCarmen Pheiffer
Aug 24, 2018·Journal of Crohn's & Colitis·Hagar TamanRuth H Paulssen
Oct 26, 2018·The British Journal of Nutrition·Khalil ElGendyJohn C Mathers
Oct 25, 2016·Nature Reviews. Cancer·Adam KinnairdEvangelos D Michelakis
Mar 29, 2013·Archives of Toxicology·Hong-Wei DongJia-Ren Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

© 2022 Meta ULC. All rights reserved