Dietary and metabolite effects on trivalent chromium retention and distribution in rats

Biological Trace Element Research
R A Anderson, M M Polansky

Abstract

The purpose of this study was to determine if diet or various metabolites alter chromium (Cr) uptake and distribution in rats. Radioactively labeled Cr was detected within 15 min of oral administration to rats, and the total amount retained remained relatively constant from 1 to 24 h. Dietary Cr intake did not alter Cr retention or distribution. The majority of the Cr was retained in the carcass. However, when the amount of labeled Cr was expressed per gram of tissue, the highest amounts of Cr were found in the kidneys, spleen, and pancreas. Pharmacological doses of insulin, epinephrine, glucagon, and dibutyryladenosine-3'-5'cyclic monophosphate, prostaglandins A1, A2, B1, B2, E1, E2, F1 alpha, and F2 alpha did not significantly influence Cr retention. Glucose, sucrose, nicotinic acid, glutathione, and other metabolites administered orally in conjunction with labeled Cr also did not significantly alter Cr retention. These data indicate that most nutrients and metabolites do not alter Cr retention and distribution. The regulation of Cr homeostasis appears to be at the level of excretion.

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Citations

Dec 31, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Buffie J ClodfelderJohn B Vincent
Apr 9, 2004·The Proceedings of the Nutrition Society·John B Vincent
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Agnieszka Scibior, Halina Zaporowska
Jan 9, 2013·Biological Trace Element Research·Sharifa T LoveJohn B Vincent
Dec 9, 2004·Journal of Animal Physiology and Animal Nutrition·B KróliczewskaA Kaczmarek-Oliwa
Apr 18, 2015·British Journal of Pharmacology·Geng-Ruei ChangFrank Chiahung Mao
Apr 27, 2010·Journal of Inorganic Biochemistry·Nicholas R RhodesJohn B Vincent

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