Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood.

The Journal of Allergy and Clinical Immunology. in Practice
Kathleen Lee-SarwarAugusto A Litonjua

Abstract

Polyunsaturated fatty acids (PUFAs) influence immune function and risk of allergic disease. Prior evidence of the effect of PUFA intake on childhood asthma and allergy is inconclusive. To investigate associations of PUFA plasma levels and dietary intake with asthma and allergy at age 3 years in this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial. Plasma PUFA levels were reported as relative abundances from mass spectrometry profiling, and dietary PUFA intake was derived from food frequency questionnaire responses. Associations between PUFA and outcomes, including asthma and/or recurrent wheeze, allergic sensitization, and total IgE at age 3 years, were evaluated in adjusted regression models. Additional regression models analyzed the combined effects of antenatal vitamin D and early childhood PUFA on outcomes. Total, omega-3, and omega-6 plasma PUFA relative abundances were significantly (P < .05) inversely associated with both asthma and/or recurrent wheeze and allergic sensitization. Likewise, dietary PUFA intake was inversely associated with asthma and/or recurrent wheeze (P < .05 for omega-6 PUFA only). For both dietary and plasma measures of total, omega-3, and omega-6 PUFAs, inverse associations with ou...Continue Reading

Citations

Mar 30, 2019·American Journal of Respiratory and Critical Care Medicine·Maria José Rosa, Matthew S Perzanowski
Jul 15, 2020·Journal of Breath Research·Jonathan LawsonJonathan Beauchamp
Sep 26, 2020·Frontiers in Pharmacology·Astrid HogenkampLinette E M Willemsen
Dec 7, 2019·The Journal of Allergy and Clinical Immunology·Maria José RosaKecia N Carroll
Feb 19, 2021·Scientific Reports·Sowmya CharyKenneth B Christopher
Mar 28, 2019·The Journal of Allergy and Clinical Immunology·Kathleen A Lee-SarwarAugusto A Litonjua
Jun 14, 2021·The Journal of Allergy and Clinical Immunology·Zhaozhong ZhuKohei Hasegawa
Jun 23, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Julie D FlomKecia Carroll
Nov 16, 2021·The Journal of Allergy and Clinical Immunology·Randi K JohnsonMichelle Daya
Jan 26, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Michael SchatzRobert S Zeiger

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