PMID: 9436249Jan 22, 1998Paper

Dietary antioxidant supplementation did not affect declining sperm function with age in the mouse but did increase head abnormalities and reduced sperm production

Reproduction, Nutrition, Development
J TenJ J Tarín

Abstract

The present study aims to ascertain whether dietary administration of a mixture of vitamins C and E may prevent the negative effects of paternal age on male fertility variables in the mouse. Experimental males were fed a standard diet supplemented with either a low or high dose of vitamins C and E. Oocytes enclosed in cumulus masses were inseminated using a 2 x 2 factorial design established according to whether males were young (3-4 months of age) or aged (22-24 months of age) and whether they were fed a control or antioxidant diet. Aged males showed a significant decrease in number of spermatozoa/mg epididymis when compared to young males. Dietary supplementation with low doses of vitamins C and E did not have any effect on sperm quality, fertilization and conceptus development in vitro. However, high doses of dietary vitamins C and E decreased the number of spermatozoa/mg epididymis, and increased the percentage of spermatozoa with misshapen heads distended in the distal part. These findings suggest that dietary supplementation with pharmacological doses of vitamins C and E may disturb spermatogenesis. The mechanism involved may be associated with either the antioxidant properties of vitamins C and E or their inhibitory acti...Continue Reading

Citations

May 30, 2002·Biological Chemistry·Matilde Maiorino, Fulvio Ursini
Dec 22, 2009·Reproductive Biomedicine Online·Francesco M LanzafameAldo E Calogero
Aug 19, 2011·Journal of Evolutionary Biology·M GarrattJ L Hurst
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause

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