Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development

Food & Function
C Simó, V García-Cañas

Abstract

There is a growing body of clinical evidence that supports a strong association between elevated circulating trimethylamine N-oxide (TMAO) levels with increased risk of developing adverse cardiovascular outcomes such as atherosclerosis and thrombosis. TMAO is synthesized through a meta-organismal stepwise process that involves (i) the microbial production of TMA in the gut from dietary precursors and (ii) its subsequent oxidation to TMAO by flavin-containing monooxygenases in the liver. Choline, l-carnitine, betaine, and other TMA-containing compounds are the major dietary precursors of TMA. TMAO can also be absorbed directly from the gastrointestinal tract after the intake of TMAO-rich foods such as fish and shellfish. Thus, diet is an important factor as it provides the nutritional precursors to eventually produce TMAO. A number of studies have attempted to associate circulating TMAO levels with the consumption of diets rich in these foods. On the other hand, there is growing interest for the development of novel food ingredients that reduce either the TMAO-induced damage or the endogenous TMAO levels through the interference with microbiota and host metabolic processes involved in TMAO pathway. Such novel functional food ing...Continue Reading

References

Jan 1, 1994·Antonie van Leeuwenhoek·J R Andreesen
Jun 1, 1995·The American Journal of Clinical Nutrition·W C WillettD Trichopoulos
Aug 16, 2002·Current Opinion in Biotechnology·Lone Gram, Paw Dalgaard
May 6, 2003·The Journal of Nutrition·Steven H ZeiselJoanne M Holden
Sep 15, 2004·Molecular Aspects of Medicine·Alison SteiberCharles L Hoppel
Oct 14, 2005·Advances in Microbial Physiology·Sharon L McCrindleAlastair G McEwan
Oct 7, 2006·Journal of Proteome Research·Cinzia StellaJeremy K Nicholson
Jul 10, 2007·Journal of Agricultural and Food Chemistry·Janine EyDirk Taubert
Dec 18, 2009·Analytical and Bioanalytical Chemistry·Jingjing XuZhong Chen
Dec 22, 2010·International Journal of Epidemiology·Miguel Ángel Martínez-GonzálezUNKNOWN PREDIMED Study Investigators
Dec 24, 2010·The American Journal of Clinical Nutrition·Aifric O'SullivanLorraine Brennan
Aug 26, 2011·The American Journal of Clinical Nutrition·Amanda J LloydJohn Draper
Sep 3, 2011·Science·Gary D WuJames D Lewis
Dec 15, 2011·Public Health Nutrition·Anna Bach-FaigUNKNOWN Mediterranean Diet Foundation Expert Group
Aug 21, 2012·PloS One·Miguel Angel Martínez-GonzálezUNKNOWN PREDIMED Study Investigators
Nov 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Smaranda Craciun, Emily P Balskus
Feb 26, 2013·The New England Journal of Medicine·Ramón EstruchUNKNOWN PREDIMED Study Investigators
Apr 26, 2013·The New England Journal of Medicine·W H Wilson TangStanley L Hazen
Jan 24, 2014·PloS One·Luigi ServilloMaria Luisa Balestrieri
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yijun ZhuYin Chen
Mar 29, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Jaana HartialaUNKNOWN CARDIoGRAM Consortium
Apr 12, 2014·Journal of Bioscience and Bioengineering·Xiang GaoYuming Wang
Apr 15, 2014·Journal of the Academy of Nutrition and Dietetics·Allyson A WestBonny Burns-Whitmore
Jun 20, 2014·The American Journal of Clinical Nutrition·Carolyn A MillerSteven H Zeisel
Jan 1, 2015·The Journal of Biological Chemistry·Jill C GregoryStanley L Hazen
Aug 13, 2015·Nutrition Research·Nabil E BoutagyKevin P Davy
Aug 15, 2015·Annual Review of Microbiology·Gwen FalonyJeroen Raes
Sep 12, 2015·Cell Death & Disease·C LebeaupinB Bailly-Maitre

❮ Previous
Next ❯

Citations

Feb 18, 2021·Current Atherosclerosis Reports·Minu S Thomas, Maria Luz Fernandez
Mar 7, 2021·Foods·Michihiro Sugano, Ryosuke Matsuoka
May 22, 2021·Critical Reviews in Food Science and Nutrition·Riya RajeevJoseph Selvin
Jun 22, 2021·Frontiers in Nutrition·Rannapaula Lawrynhuk Urbano FerreiraLucia Fatima Campos Pedrosa
Aug 24, 2021·Frontiers in Psychiatry·Mariana RomanenkoAlexander Vaiserman
Nov 6, 2021·Critical Reviews in Food Science and Nutrition·Zhenyu WangZhiyong He

❮ Previous
Next ❯

Methods Mentioned

BETA
amplicon sequencing
NMR

Software Mentioned

PREDIMED

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.