PMID: 18716166Aug 22, 2008Paper

Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice

The Journal of Nutrition
Kan YangM Lipkin

Abstract

Both epidemiological and experimental findings have indicated that components of Western diets influence colonic tumorigenesis. Among dietary constituents, calcium and cholecalciferol have emerged as promising chemopreventive agents. We have demonstrated that a Western-style diet (WD) with low levels of calcium and cholecalciferol and high levels of (n-6) PUFA, increased the incidence of neoplasia in mouse intestine compared with a standard AIN-76A diet; models included wild-type mice and mice with targeted mutations. In the present study, adenomatous polyposis coli (Apc)(1638N/+) mice carrying a heterozygous Apc mutation were fed either an AIN-76A diet, a WD, or a WD supplemented with calcium and cholecalciferol (WD/Ca/VitD3). Diets were fed for 24 wk and effects on cellular and molecular events were assessed by performing immunohistochemistry in colonic epithelium along the crypt-to-surface continuum. Feeding WD to Apc(1638N/+) mice not only enhanced cyclin D1 expression in colonic epithelium compared with AIN-76A treatment as previously reported but also significantly increased the expression of the antiapoptotic protein B-cell lymphoma 2 (Bcl-2) concomitantly with a decrease in the proapoptotic Bcl2-associated X protein and...Continue Reading

References

Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·R FoddeP M Khan
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·P J MorinK W Kinzler
Aug 17, 1999·Annual Review of Nutrition·M LipkinS A Lamprecht
Feb 11, 2000·Annals of the New York Academy of Sciences·M LipkinR Kucherlapati
Feb 11, 2000·Annals of the New York Academy of Sciences·L H AugenlichtA Velcich
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Mar 20, 2002·Vitamins and Hormones·Timo YlikomiPentti Tuohimaa
May 6, 2003·Biochemical and Biophysical Research Communications·György HajnóczkyMuniswamy Madesh
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Aug 2, 2003·Nature Reviews. Cancer·Sergio A Lamprecht, Martin Lipkin
Aug 16, 2003·Nutrition Reviews·Sergio A Lamprecht, Martin Lipkin
Nov 25, 2003·Oncogene·Rosario RizzutoTullio Pozzan
Jul 3, 2004·Nutrition and Cancer·William B Grant, Cedric F Garland
Aug 28, 2004·Endocrinology·Maofu FuRichard G Pestell
Apr 13, 2005·Gastroenterology·John M MariadasonLeonard H Augenlicht
May 19, 2005·The Journal of Biological Chemistry·Jinyi ShaoHongmiao Sheng
Aug 25, 2005·Gut·D Wang, R N Dubois
Oct 28, 2005·The Journal of Nutrition·Kan YangLeonard Augenlicht
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Jeffrey A MeyerhardtCharles S Fuchs
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson

❮ Previous
Next ❯

Citations

Nov 12, 2009·International Journal of Cancer. Journal International Du Cancer·Wenfeng FangWancai Yang
Jul 20, 2013·BMC Public Health·Wahyu WulaningsihMieke Van Hemelrijck
Oct 17, 2019·Genes·Monika StastnaVladimir Korinek
Feb 18, 2011·International Journal of Cancer. Journal International Du Cancer·Wei ZhengYan Chun Li
Jun 2, 2016·The British Journal of Nutrition·Ruoxu DouShuji Ogino
Jan 14, 2009·World Journal of Gastroenterology : WJG·Minna Nystrom, Marja Mutanen
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Cindy D Davis, John A Milner
Sep 21, 2016·Annals of the New York Academy of Sciences·Daniel D Bikle
Jan 10, 2014·Endocrine·Daniel D Bikle
Jan 16, 2013·Endocrine-related Cancer·Carlien LeyssensAnnemieke Verstuyf
Oct 16, 2018·Endocrine Reviews·Roger BouillonJohn Bilezikian
Nov 14, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Alexandra VulcanBodil Ohlsson
Dec 20, 2011·Carcinogenesis·Charles GiardinaDaniel W Rosenberg
Mar 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mathilde TouvierTeresa Norat
Aug 8, 2021·International Journal of Molecular Sciences·Waqas AlamCarla Renata Arciola
Oct 9, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lauren E BarberJulie R Palmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis