PMID: 2484428Jan 1, 1989Paper

Dietary carbohydrate influences tissue fatty acid and lipid composition in the copper-deficient rat

Biological Trace Element Research
S C CunnaneC G Lewis

Abstract

Fructose and copper have been shown independently to influence long chain fatty acid metabolism. Since fructose feeding exacerbates copper deficiency, their possible interaction with respect to tissue long chain fatty acid and lipid composition was studied. Weanling male Sprague-Dawley rats were given diets containing 0.6 or 6 mg/kg copper. The carbohydrate source (627 g/kg) was either fructose or corn starch. After 3 wk, fatty acid profiles and total lipids in heart and liver were analyzed. Copper-deficient rats fed fructose had more severe signs of copper deficiency than those fed starch, according to heart/body wt ratio, hematocrit, and liver copper content. The fatty acid composition of heart and liver triacylglycerol was significantly different between groups, but the changes did not correlate with the severity of copper deficiency. In heart, phosphatidylinositol and phosphatidylserine, arachidonic acid and docosapentaenoic acid (n-6) were increased 193 and 217%, respectively, p less than 0.05) in rats given the copper-deficient diet containing fructose. Changes in the long chain fatty acids in heart phospholipids may be related to the higher mortality commonly observed in rats fed a copper-deficient diet containing fructose.

References

Nov 1, 1979·European Journal of Biochemistry·R JeffcoatA T James
Nov 1, 1979·European Journal of Biochemistry·R JeffcoatA T James
Jan 1, 1976·Biochemical Society Transactions·P A Mayes
Nov 1, 1976·The Journal of Nutrition·L M Klevay
Jul 1, 1975·The American Journal of Clinical Nutrition·L M Klevay
Jul 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·K Y LeiJ Zhang
Apr 1, 1988·The Journal of Nutrition·G D OveckaD M Medeiros
Jul 1, 1986·The Journal of Nutrition·S C CunnaneJ R Prohaska
Nov 18, 1974·Biochimica Et Biophysica Acta·O MercuriM E de Tomás
Sep 1, 1974·Thrombosis Research·J B SmithJ J Kocsis
Mar 15, 1974·Science·M J SilverJ B Smith
Feb 1, 1984·The American Journal of Clinical Nutrition·M FieldsS Reiser
Apr 15, 1982·The Biochemical Journal·R F Irvine

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Citations

Aug 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H S TaperM Roberfroid

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