PMID: 9833908Dec 2, 1998

Dietary carbohydrate intake plays an important role in preventing alcoholic fatty liver in the rat

Journal of Hepatology
H TsukadaA Sato

Abstract

Dietary carbohydrate intake during ethanol ingestion augments the induction of hepatic cytochrome P450 2E1 (CYP2E1) by ethanol. This study addresses the role of carbohydrate intake in the development of alcoholic fatty liver in the rat. Male Sprague-Dawley rats were pair-fed on liquid diets containing ethanol (3.5 g/day, 36% of total calories) with different amounts of carbohydrate and fat for 4 weeks, and the development of fatty liver was observed biochemically and morphologically. An ethanol-containing low-carbohydrate diet (protein 17%; fat 36%; carbohydrate 11%; ethanol 36%) had more markedly adverse effects on the liver of rats than did an isocaloric ethanol-containing high-carbohydrate diet (protein 17%; fat 5%; carbohydrate 42%; ethanol 36%). The hepatic triglyceride level in the rats that consumed the low-carbohydrate diet was higher than that in the rats kept on the high-carbohydrate diet, a finding that was confirmed histologically. The ethanol-containing low-carbohydrate diet caused a marked increase in the activity of hepatic CYP2E1. The CYP2E1 protein level, as measured by Western blot analysis, matched the activity of CYP2E1, as measured by the rates of dimethylnitrosamine, p-nitrophenol and ethanol metabolism. T...Continue Reading

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Citations

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Y WangA Sato
Dec 25, 2002·Free Radical Biology & Medicine·Carmela Loguercio, Alessandro Federico
May 15, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J C RowlandsT M Badger
Oct 4, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Fred PoordadFrancis Y Yao
Jan 5, 2017·Scientific Reports·Mohamed A AbdelmegeedByoung-Joon Song

Related Concepts

Dietary Carbohydrates
Enzyme Activation
Alcoholic Steatohepatitis
Liver
Rats, Holtzman
Cytochrome P-450 CYP2E1

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