Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.

Cancer Prevention Research
Guangxun LiChung S Yang

Abstract

To develop a relevant mouse model for prostate cancer prevention research, we administered a dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), to CYP1A-humanized mice. In comparison with mouse Cyp1a2, human CYP1A2 preferentially activates PhIP to a proximate carcinogen. Following a single oral dose of PhIP (200 mg/kg body weight), we observed inflammation, atrophy of acini, low-grade prostatic intraepithelial neoplasia (PIN; after 20 weeks), and high-grade PIN (HgPIN; after 30 to 50 weeks) in dorsolateral, ventral, and coagulating anterior prostate glands of these mice. These lesions were androgen receptor positive and featured the loss of expression of the basal cell marker p63 and the tumor suppressor PTEN. Similar to human prostate carcinogenesis, glutathione S-transferase P1 (GSTP1) expression was lost or partially lost in HgPIN. E-Cadherin expression was also lost in HgPIN. The expression of DNA methyltransferase 1 was elevated, possibly to enhance promoter hypermethylation for the silencing of GSTP1 and E-cadherin. Prostate carcinogenesis was promoted by a high-fat stress diet, resulting in HgPIN that developed earlier and in advanced lesions displayed features consistent with carcinoma in situ. ...Continue Reading

References

Dec 1, 1989·Japanese Journal of Cancer Research : Gann·H EsumiT Sugimura
Dec 2, 1999·Journal of the National Cancer Institute·A E NorrishR T Jackson
Dec 14, 1999·The American Journal of Pathology·A M De MarzoW G Nelson
Dec 7, 2000·The American Journal of Pathology·S SignorettiM Loda
Aug 25, 2001·Cancer Causes & Control : CCC·D S MichaudE Giovannucci
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M ParkinS S Devesa
Aug 7, 2002·The American Journal of Pathology·Jae-Hak ParkRobert D Cardiff
Jan 2, 2004·Nature Medicine·Charlie D ChenCharles L Sawyers
Apr 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hong Gee Sim, Christopher W S Cheng
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·June M ChanEdward L Giovannucci
Dec 17, 2005·Cancer Research·Amanda J CrossRashmi Sinha
Aug 8, 2006·Mutation Research·Randa El-ZeinSara S Strom
Aug 8, 2006·The Journal of Urology·Gregory T MacLennanSanjay Gupta
Sep 21, 2006·Neoplasia : an International Journal for Oncology Research·Alexander D BorowskyRalph Devere-White
Sep 27, 2006·The American Journal of Surgical Pathology·Angelo M De MarzoM S Lucia
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Deliang TangBenjamin A Rybicki
Jun 15, 2007·Biochemical and Biophysical Research Communications·Nadine DraginDaniel W Nebert
Sep 11, 2007·Urologic Oncology·Angelo M De MarzoWilliam G Nelson
Jun 10, 2008·Expert Reviews in Molecular Medicine·Imran AhmadHing Y Leung
Mar 6, 2009·The American Journal of Clinical Nutrition·Sabine RohrmannJakob Linseisen
Jun 13, 2009·Endocrinology·William G NelsonSrinivasan Yegnasubramanian
Jul 4, 2009·Current Opinion in Pharmacology·Aditya BardiaWilliam G Nelson
Feb 10, 2010·Cancer Metastasis Reviews·Varinder JeetAparajita Khatri
Sep 17, 2010·Genes & Development·Michael M Shen, Cory Abate-Shen
Sep 24, 2010·Cancer Control : Journal of the Moffitt Cancer Center·Jong Y Park
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Jean-Alfred Thomas, Stephen J Freedland
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman

❮ Previous
Next ❯

Citations

Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·Deliang TangBenjamin A Rybicki
Dec 3, 2014·The American Journal of Pathology·Grant N BurchamTimothy L Ratliff
Mar 17, 2015·Current Pharmacology Reports·Savita SinghSanjay Gupta
Jun 10, 2016·Critical Reviews in Toxicology·Emma L MarczyloTimothy W Gant
Aug 11, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Karl-Dimiter BissigXinxin Ding
Mar 30, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Medjda BellamriRobert J Turesky
Aug 1, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabine RohrmannKana Wu
Mar 3, 2021·Food Research International·Mohammad Rizwan Khan, Mohammad Azam
Jul 18, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Medjda BellamriRobert J Turesky
Sep 2, 2021·Drug Discovery Today·Lap Hing ChiRobin L Anderson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.