Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota.

Gut Microbes
Yeji KimMi-Na Kweon

Abstract

A Western diet comprising high fat, high carbohydrate, and low fiber content has been suggested to contribute to an increased prevalence of colitis. To clarify the effect of dietary cellulose (an insoluble fiber) on gut homeostasis, for 3 months mice were fed a high-cellulose diet (HCD) or a low-cellulose diet (LCD) based on the AIN-93G formulation. Histologic evaluation showed crypt atrophy and goblet cell depletion in the colons of LCD-fed mice. RNA-sequencing analysis showed a higher expression of genes associated with immune system processes, especially those of chemokines and their receptors, in the colon tissues of LCD-fed mice than in those of HCD-fed mice. The HCD was protective against dextran sodium sulfate-induced colitis in mice, while LCD exacerbated gut inflammation; however, the depletion of gut microbiota by antibiotic treatment diminished both beneficial and non-beneficial effects of the HCD and LCD on colitis, respectively. A comparative analysis of the cecal contents of mice fed the HCD or the LCD showed that the LCD did not influence the diversity of gut microbiota, but it resulted in a higher and lower abundance of Oscillibacter and Akkermansia organisms, respectively. Additionally, linoleic acid, nicotinat...Continue Reading

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Citations

Nov 25, 2020·International Journal of Molecular Sciences·Rosa LombardiAnna Ludovica Fracanzani
Feb 2, 2021·Frontiers in Pediatrics·Heather ArmstrongEytan Wine
Nov 20, 2020·Phytotherapy Research : PTR·Xiao SongYue Geng
Mar 2, 2021·Experimental Biology and Medicine·Kirsten BerdingJohn F Cryan
Mar 12, 2021·Advances in Nutrition·Kirsten BerdingJohn F Cryan
Aug 26, 2020·The Journal of Allergy and Clinical Immunology·Hugo Charles-MessanceHelen M Roche
Apr 29, 2021·Molecular Nutrition & Food Research·Stefan KabischAndreas F H Pfeiffer

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Datasets Mentioned

BETA
PRJNA592599

Methods Mentioned

BETA
flow cytometry
PMA
PCR
PCRs
chip
PCA

Software Mentioned

HMMER
Prism
Metabolomics Workbench
VSEARCH
EzBioCloud
HISAT
Trimmomatic
ImageJ
nhmmer
MetaboAnalyst

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