PMID: 11606014Oct 19, 2001Paper

Dietary chloride as a possible determinant of the severity of exercise-induced asthma

European Journal of Applied Physiology
T D MickleboroughLoren Cordain

Abstract

Dietary sodium chloride (NaCl) has been shown to alter the severity of exercise-induced asthma, but it is not known if the sodium and chloride ions have independent effects in this regard. The hypothesis tested in the present study was that both a low sodium, low chloride diet and a high sodium, low chloride diet would improve post-exercise pulmonary function in subjects with exercise-induced asthma (EIA) compared to a normal NaCl diet (NSD); but that neither of these diets would have an effect on post-exercise pulmonary function in control (non-EIA) subjects. Eight subjects who suffered from EIA and eight subjects who did not (control) took part in a double-blind crossover study. Pre- and post-exercise pulmonary function was assessed after 2 weeks on a NSD, a low NaCl diet (LSD, low sodium, low chloride) or a sodium bicarbonate diet (NaHCO3 diet, high sodium, low chloride). A 1 week washout period occurred between diets. Altering dietary sodium or chloride had no effect on pre-exercise (baseline) pulmonary function in either group or on post-exercise pulmonary function in control subjects. However, both the LSD and the NaHCO3 diet lessened the deterioration in post-exercise pulmonary function in EIA subjects. Comparing results...Continue Reading

Citations

Jan 27, 2012·Research Quarterly for Exercise and Sport·Ronald K HetzlerIris F Kimura
Jun 27, 2008·Exercise and Sport Sciences Reviews·Timothy D Mickleborough
Nov 18, 2006·International Journal of Clinical Practice·T D Mickleborough, A Fogarty
Aug 9, 2003·American Journal of Respiratory and Critical Care Medicine·Timothy D MickleboroughMartin R Lindley
May 3, 2008·American Journal of Respiratory and Critical Care Medicine·Zara E K PogsonAndrew W Fogarty
Oct 1, 2008·Respiratory Research·Tricia M McKeeverJohn Britton
Mar 5, 2003·Clinics in Sports Medicine·Jonathon Truwit
Jul 25, 2003·Pediatric Clinics of North America·Ketan K Sheth
Sep 9, 2004·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Timothy D Mickleborough, Robert W Gotshall
Apr 29, 2010·The Physician and Sportsmedicine·Timothy D Mickleborough
Mar 18, 2011·The Cochrane Database of Systematic Reviews·Zara Pogson, Tricia McKeever
Aug 1, 2002·Drugs·Robert W Gotshall
Feb 9, 2005·The American Journal of Clinical Nutrition·Loren CordainJanette Brand-Miller

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