Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit's Nictitating Membrane Response.

International Journal of Alzheimer's Disease
Bernard G SchreursJimena Gonzalez-Joekes

Abstract

A rabbit model of Alzheimer's disease based on feeding a cholesterol diet for eight weeks shows sixteen hallmarks of the disease, including learning and memory changes. Although we have shown 2% cholesterol and copper in water can retard learning, other studies show feeding dietary cholesterol before learning can improve acquisition whereas feeding cholesterol after learning can degrade long-term memory. We explored this issue by manipulating cholesterol concentration and duration following classical trace conditioning of the rabbit's nictitating membrane response and assessed conditioned responding after eight weeks on cholesterol. First, rabbits given trace classical conditioning followed by 0.5%, 1%, or 2% cholesterol for eight weeks showed body weight and serum cholesterol levels that were a function of dietary cholesterol. Although all concentrations of cholesterol showed some sign of retarding long-term memory, the level of memory retardation was correlated with serum cholesterol levels. Second, rabbits given trace conditioning followed by different durations of a 2% cholesterol diet combined with different durations of a 0% control diet for 8 weeks showed duration and timing of a 2% cholesterol diet were important in aff...Continue Reading

References

Dec 1, 1977·Atherosclerosis·C W Adams, R S Morgan
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·M Upchurch, J M Wehner
Dec 1, 1971·Journal of Comparative and Physiological Psychology·S R Coleman, I Gormezano
May 1, 1966·Psychological Review·H D Kimmel
Nov 1, 1981·The Journal of Clinical Investigation·P D Henry, K I Bentley
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·S Miller, J M Wehner
Mar 1, 1996·Neurobiology of Aging·D L Sparks
Jul 17, 1998·Metabolism: Clinical and Experimental·G XuG Salen
Jul 23, 1999·Toxicology and Industrial Health·S Siegel
May 10, 2000·Behavioural Brain Research·S C Woods, D S Ramsay
Aug 11, 2000·Microscopy Research and Technique·D L SparksJ C Hunsaker
Jan 6, 2001·Behavioral Neuroscience·A P WeibleJ F Disterhoft
Feb 7, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·Y Stein, O Stein
Nov 13, 2001·International Journal of Experimental Pathology·D J LambG A Ferns
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·D T SteinI Jialal
Jan 26, 2002·Behavioural Brain Research·W T O'BrienR J Servatius
Feb 21, 2002·Behavioural Brain Research·Vootele VõikarElina Ikonen
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·Paolo ZattaFederico Licastro
Sep 18, 2002·Experimental and Clinical Psychopharmacology·Shepard Siegel, Barbara M C Ramos
Jun 1, 1995·Gender and Development·R J Cook
Aug 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·D Larry Sparks, Bernard G Schreurs
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akinobu SuzukiSatoshi Kida
Jun 19, 2004·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·Andrew R Delamater
Jun 23, 2004·Laboratory Animals·Amalia E Yanni
Oct 7, 2004·Learning & Memory·Mark E Bouton
Oct 7, 2004·Learning & Memory·Karla RobletoRichard F Thompson
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·J W RudyP Matus-Amat
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Feb 17, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard J Servatius, Kevin D Beck
Feb 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mari Carmen IndaAngel Manuel Carrión
Mar 3, 2005·Journal of Lipid Research·Maura HeverinIngemar Björkhem
May 17, 2005·Neurobiology of Aging·Ruth M BarrientosSteven F Maier
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jacek DebiecJoseph E Ledoux
May 4, 2006·Nutritional Neuroscience·S YehudaD I Mostofsky
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wen-Hui CaiCraig M Powell
Nov 23, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·James C Russell, Spencer D Proctor

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