PMID: 11333839May 3, 2001Paper

Dietary cholesterol is secreted in intestinally derived chylomicrons during several subsequent postprandial phases in healthy humans

The American Journal of Clinical Nutrition
G Beaumier-GallonD Lairon

Abstract

The process of intestinal absorption and chylomicron resecretion of dietary cholesterol in humans is poorly understood. The present study aimed to test the hypothesis that dietary cholesterol ingested during a given meal is resecreted into chylomicrons (and plasma) during several subsequent postprandial periods. Seven healthy subjects ingested 3 comparable mixed test meals (at 0, 8, and 24 h) containing a given amount of fat (49 g) and cholesterol (157 mg); blood samples were taken 3 and 6 h after each test meal and 48 and 72 h after the beginning of the experiment. Heptadeuterated dietary cholesterol was present in the first test meal only, enabling its specific determination with use of gas chromatography-mass spectrometry. Chylomicrons, LDL, and HDL were isolated and lipids were quantified. In apolipoprotein B-48-containing chylomicrons, deuterated cholesterol concentrations were moderate after the first meal (1.3 x 10(-4) mmol/L), reached a maximum after the second meal (2.4 x 10(-4) mmol/L), and were still elevated after the third meal (1.7 x 10(-4) mmol/L). In plasma, LDL and HDL cholesterol enrichment in deuterated cholesterol was lower than in chylomicrons and plateaued after 24--48 h. Estimates of newly secreted exogen...Continue Reading

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Citations

Oct 13, 2006·Current Opinion in Gastroenterology·Richard E Ostlund
Oct 17, 2001·Current Atherosclerosis Reports·E J Parks
May 31, 2003·The Journal of Biological Chemistry·Jahangir IqbalM Mahmood Hussain
Aug 29, 2006·Journal of Lipid Research·Emily J WestoverRichard E Ostlund
Jun 5, 2008·European Journal of Clinical Nutrition·S S AbuMweisP J H Jones
Aug 11, 2012·European Journal of Nutrition·Marie Josèphe AmiotDenis Lairon
Apr 26, 2007·European Journal of Clinical Nutrition·D LaironC Williams
Sep 10, 2019·The American Journal of Clinical Nutrition·Emmanuelle Reboul
Aug 12, 2008·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Genovefa D KolovouDennis V Cokkinos
Oct 22, 2008·Current Atherosclerosis Reports·Suhad S AbuMweis, Peter J H Jones
Mar 22, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Maite M SchroorRonald P Mensink
Aug 30, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Takanari NakanoTakayuki Murakoshi
Mar 22, 2002·Biochemical and Biophysical Research Communications·Dominique Jourdheuil-RahmaniDenis Lairon
Oct 3, 2003·Biochemical and Biophysical Research Communications·Barbara PlayDominique Jourdheuil-Rahmani
Dec 21, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jyrki J AgrenHelena Gylling
Aug 29, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Kim G JacksonChristine M Williams
Jul 4, 2008·Atherosclerosis. Supplements·Denis Lairon

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