Dietary cholesterol lowers liver copper in rabbits

Biological Trace Element Research
L M Klevay

Abstract

Atherosclerosis and hypercholesterolemia have been produced in rabbits since 1913 by feeding them cholesterol. These experiments have a great influence on current thinking about the etiology and possible prevention of ischemic heart disease. Male, New Zealand White rabbits were fed 0.5% dietary cholesterol. Cholesterol and copper in plasma increased sixty-fold and 50%, respectively. Liver copper decreased 74% and hematocrit decreased 26%. Iron was unchanged in heart and liver, but was increased in kidney. Zinc was decreased in heart, but was unchanged in liver or kidney. Changes in organ iron and zinc were smaller than the decrease in liver copper. Similar experiments with higher doses of dietary cholesterol may have resulted in copper deficiency. It may be appropriate to revise interpretations of data from these experiments and to reformulate hypothesis based on the data. Results are consonant with the theoretical implication of copper metabolism and copper deficiency in the etiology and pathogenesis of ischemic heart disease.

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Citations

Sep 2, 2003·The Journal of Nutritional Biochemistry·Ingeborg D de WolfHein A van Lith
Oct 11, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Leslie M Klevay
Sep 27, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Kothapa N ChettySrikrishna N Chetty
Mar 9, 2017·IUBMB Life·Austin MorrellJason L Burkhead
Dec 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Leslie M Klevay
Apr 24, 2020·Journal of the Science of Food and Agriculture·Leslie M Klevay
Jul 10, 2019·American Journal of Physiology. Endocrinology and Metabolism·Leslie M Klevay
Feb 19, 2004·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ingeborg de WolfHein van Lith
Aug 9, 2021·Biochimica Et Biophysica Acta. General Subjects·Bryce BladesSharon La Fontaine

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