Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neurons.

Neuroscience Letters
Desheng Wang, Bernard G Schreurs

Abstract

Previous work has shown high dietary cholesterol can affect learning and memory including rabbit eyeblink conditioning and this effect may be due to increased membrane cholesterol and enhanced hippocampal amyloid beta production. This study investigated whether dietary cholesterol modulates rabbit hippocampal CA1 neuron membrane properties known to be involved in rabbit eyeblink conditioning. Whole-cell current clamp recordings in hippocampal neurons from rabbits fed 2 percent cholesterol or normal chow for 8 weeks revealed changes including decreased after-hyperpolarization amplitudes (AHPs) - an index of membrane excitability shown to be important for rabbit eyeblink conditioning. This index was reversed by adding copper to drinking water - a dietary manipulation that can retard rabbit eyeblink conditioning. Evidence of cholesterol effects on membrane excitability was provided by application of methyl-beta-cyclodextrin, a compound that reduces membrane cholesterol, which increased the excitability of hippocampal CA1 neurons.

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Citations

May 17, 2012·PloS One·Kiel G OrmerodA Joffre Mercier
Sep 28, 2013·International Journal of Alzheimer's Disease·Bernard G Schreurs
Feb 21, 2014·Molecular Neurobiology·Xiaoguang YangJames C-M Lee
Jun 17, 2014·Developmental Neurobiology·Desheng Wang, Bernard G Schreurs
Jun 16, 2015·Frontiers in Neuroscience·Donghui ZhuSholpan Askarova
Aug 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Desheng WangBernard G Schreurs
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Desheng Wang
Dec 8, 2020·Neurobiology of Learning and Memory·Deidre E O'DellDesheng Wang

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