Dietary chromium decreases insulin resistance in rats fed a high-fat, mineral-imbalanced diet

Metabolism: Clinical and Experimental
J S StrifflerR A Anderson

Abstract

The effects of chromium (Cr) supplementation on diet-induced insulin resistance produced by feeding a high-fat, low-Cr diet were studied in rats to ascertain the role of Cr in insulin resistance. Wistar male rats were maintained for 16 weeks after weaning on a basal diet containing 40% lard, 30% sucrose, and 25% casein by weight and adequate vitamins and minerals without added Cr (-Cr). Fasting levels of insulin, glucose, and triglycerides and the responses during an intravenous glucose tolerance test (IVGTT) were compared as indices of insulin resistance and the effectiveness of dietary Cr. IVGTTs and blood sampling for data analyses were performed over a 40-minute period after IV glucose injection (1.25 g/kg body weight) in overnight-fasted animals under pentobarbital anesthesia (40 mg/kg body weight). All animals were normoglycemic (-Cr, 109 +/- 3 mg/dL; +Cr, 119 +/- 5), with fasting insulin levels elevated in the -Cr group (65 +/- 10 microU/mL) versus the +Cr group (31 +/- 4 microU/mL). Increases in plasma triglycerides in the -Cr group were not significant. Following glucose injection, the rate of glucose clearance was lower in the -Cr group (1.74 +/- 0.22 v2.39 +/- 0.11%/min), and 40-minute glucose areas in the -Cr group ...Continue Reading

References

Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
May 1, 1989·Experimental and Clinical Endocrinology·G HübnerK Hartmann
Mar 1, 1986·Diabetes·A L VallerandL J Bukowiecki
Apr 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M FieldsJ C Smith
May 1, 1982·The Journal of Clinical Investigation·C N Sadur, R H Eckel
Oct 1, 1995·Metabolism: Clinical and Experimental·J S StrifflerR A Anderson
Jul 1, 1993·The Journal of Clinical Endocrinology and Metabolism·J M Miles, M D Jensen
Jun 14, 1993·Annals of the New York Academy of Sciences·M M WiersmaJ K Radder

❮ Previous
Next ❯

Citations

Dec 31, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Buffie J ClodfelderJohn B Vincent
Jul 20, 2002·The International Journal of Biochemistry & Cell Biology·Vanderlei FolmerJ B T Rocha
Dec 1, 2003·Nutrition Research Reviews·Richard A Anderson
Feb 20, 2004·Public Health Nutrition·N P SteynA Louheranta
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·H G Preuss, R A Anderson
Jan 8, 2008·Clinical and Experimental Pharmacology & Physiology·Dae Keun KwonYoung-Ju Song
Aug 17, 1999·Annual Review of Nutrition·H C Lukaski
Dec 21, 2010·Diabetology & Metabolic Syndrome·Nicolas Wiernsperger, Jeanrobert Rapin
Nov 19, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Kristin R Di BonaJohn B Vincent
Jul 22, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·John B Vincent
Aug 21, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fawzia M RefaieWael H Aboul Nour
Mar 8, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Monika KrzysikRyszard Weber
Oct 7, 2008·The Veterinary Journal·Alberto MantovaniCinzia La Rocca
Sep 15, 2012·Chemistry & Biodiversity·John B Vincent, Sharifa T Love
Sep 15, 2010·Statistics in Medicine·Pulak GhoshRam C Tiwari
Jun 22, 2000·Nutrition Reviews·K RobertsC K Lardinois
Apr 27, 2010·Journal of Inorganic Biochemistry·Nicholas R RhodesJohn B Vincent
Aug 25, 1999·Metabolism: Clinical and Experimental·J S StrifflerR A Anderson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved