Dietary combination of fish oil and taurine decreases fat accumulation and ameliorates blood glucose levels in type 2 diabetic/obese KK-A(y) mice

Journal of Food Science
Nana MikamiKazuo Miyashita

Abstract

n-3 Polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and taurine are functional compounds abundantly present in seafoods. In this study, we examined the combined effects of EPA- and DHA-rich fish oil and taurine on white adipose tissue (WAT) weight and blood glucose levels in diabetic/obese KK-A(y) mice. After a 4-wk administration of experimental diets (soybean oil or fish oil, supplemented with 0%, 2%, or 4% taurine), the increase in WAT weight of the mice fed the "fish oil + 4% taurine" diet was significantly suppressed compared to the "soybean oil + 4% taurine" and "fish oil only" diets. Serum triglycerides, free fatty acids, and total cholesterol levels decreased by fish oil administration. In addition, fish oil and taurine increased the activity of acyl-CoA oxidase, which is the rate-limiting enzyme of peroxisomal β-oxidation, increased in the liver of KK-A(y) mice. The activity of fatty acid synthase decreased by fish oil diets. Furthermore, blood glucose and insulin levels were significantly lower in the mice fed fish oil than in the soybean oil-fed mice. In fish oil + 4% taurine group, hyperglycemia and hyperinsulinemia were effectively improved in KK-A(y) mice com...Continue Reading

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Citations

May 30, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Julia B EwaschukVera C Mazurak
Jul 30, 2015·Prostaglandins & Other Lipid Mediators·Leyre Martínez-FernándezMaría J Moreno-Aliaga
Mar 20, 2015·Molecular Nutrition & Food Research·Shigeru Murakami
Mar 13, 2017·Behavioural Brain Research·Isadora Pozzetti SibaJanaína Menezes Zanoveli
Sep 27, 2018·Molecular Nutrition & Food Research·Chaoyue WenYulong Yin
Feb 26, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Shiwei HuYu Liu
Oct 11, 2017·Journal of Food and Drug Analysis·Chen-Yuan ChiuMeng-Tsan Chiang
Jun 30, 2021·Molecular Medicine Reports·Stella BaliouVassilis Zoumpourlis

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