Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency

Scientific Reports
Yu ZhangCheng Huang

Abstract

Studies on peroxisome proliferator-activated receptor (PPAR)-γ ligands have been focused on agonists. However, PPARγ activation may induce obesity and nonalcoholic fatty liver disease (NAFLD), one of the most challenging medical conditions. Here, we identified that isorhamnetin, a naturally occurring compound in fruits and vegetables and the metabolite of quercetin, is a novel antagonist of PPARγ. Isorhamnetin treatment inhibited the adipocyte differentiation induced by the PPARγ agonist rosiglitazone, reduced obesity development and ameliorated hepatic steatosis induced by both high-fat diet treatment and leptin deficiency. Our results suggest that dietary supplement of isorhamnetin may be beneficial to prevent obesity and steatosis and PPARγ antagonists may be useful to treat hepatic steatosis.

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Citations

Aug 23, 2017·International Journal of Molecular Sciences·Marilena Antunes-RicardoSergio O Serna-Saldívar
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mak-Soon Lee, Yangha Kim
Jun 20, 2019·Current Drug Targets·Yingying ShiFujiang Guo
Feb 8, 2020·Journal of Cellular and Molecular Medicine·Liwei WuJianye Wu
Jun 27, 2020·International Journal of Molecular Sciences·Shih-Yi LinChun-Jung Chen
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Dec 19, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Der Jiun OoiMaznah Ismail

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Methods Mentioned

BETA
Fluorescence
scanning electron microscopy
FRET
transfection
Assay
transfections
PCR
enzyme-linked immunosorbent
fluorescence resonance

Software Mentioned

GraphPad Prism
MOE2012

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