PMID: 7015072Jun 1, 1981Paper

Dietary control of pathogenesis in C57BL/KsJ db/db diabetes mice

Metabolism: Clinical and Experimental
E H LeiterI Strack

Abstract

Weanling C57BL/KsJ homozygous diabetic (db/db) and normal littermate (+/+ or +/db) mice were maintained for 5 mon on isocaloric diets containing either 60% sucrose, 23% casein, 8% corn oil (diet C) or 0% sucrose, 83% casein, 8% corn oil (diet B). Diabetic homozygotes consumed more diet C than normals, but ate control amounts of diet B. Diabetic mice fed diet C exhibited 57% mortality between 4 or 5 mo of age. All diabetic mutants fed the carbohydrate-free diet B appeared healthy at 6 mo of age; mutant females were normoglycemic and mutant males were only moderately hyperglycemic. Histological examination of pancreatic islets confirmed the absence of islet degeneration. In diet B maintained mutants, increased carcass fat composition, plasma and pancreatic content of insulin and glucagon, and thymidine incorporation into islets, all established that the db gene was being fully expressed. These results indicate that dietary protein stimulates islet growth and function in db/db mice, while high levels of refined carbohydrate in the diet predispose islet beta cells to undefined changes that culminate in necrosis. Restricting mutants' intake of a carbohydrate-containing diet to one-half the caloric intake of normal mice failed to blo...Continue Reading

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Citations

Oct 1, 1992·Diabetes/metabolism Reviews·E Shafrir
Dec 1, 1991·The Proceedings of the Nutrition Society·L Herberg
Jun 8, 2000·Annals of the New York Academy of Sciences·E ShafrirL Mosthaf
Jul 12, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Karyn A EsserMing C Gong
Aug 26, 2014·Inflammopharmacology·Manpreet KaurPuneet Kumar
Sep 1, 1996·Acta Diabetologica·K SchneiderT Linn
Jun 12, 2004·The Journal of Investigative Dermatology·Ghada NaguibDana T Graves
Sep 7, 2007·Neurobiology of Disease·Kelli A SullivanEva L Feldman
Apr 1, 1992·Diabetes Research and Clinical Practice·K B HuhJ W Yoon
Feb 18, 2015·Biochimica Et Biophysica Acta·R Charlotte MoffettPeter R Flatt
Jan 1, 1993·Critical Reviews in Food Science and Nutrition·E H Leiter
Mar 26, 2005·Journal of Dental Research·D T GravesE Krall
May 8, 2014·American Journal of Physiology. Endocrinology and Metabolism·Kim V AndreassenKim Henriksen

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