Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration

European Journal of Nutrition
Yilong DongCai Song

Abstract

Interleukin (IL)-1β can activate glial cells to trigger neuroinflammation and neurodegeneration. Lower omega (n)-3 polyunsaturated fatty acids (PUFAs) and lower n-3/n-6 PUFA ratios occur in the brain of patients with Alzheimer's disease (AD). We have previously reported that an n-3 PUFA, eicosapentaenoic acid (EPA), can improve memory and attenuate neurodegeneration-like changes in animal models of AD. However, whether and how EPA modulates glial cell activity and functions remains unclear. The aim of this study was to test the hypothesis that EPA may attenuate neuroinflammation by inhibiting microglial activation and microglia-produced proinflammatory cytokines, and by enhancing the expression of astrocytes-produced neurotrophins and their receptors. Male Long-Evans rats were fed either palm oil supplemented diet or EPA supplemented diet for 42 days. On day 36 of diet feeding, rats received an intracerebroventricular injection of IL-1β or saline for 7 days. The glial activation, the expression of amyloid precursor protein (APP), calcium-dependent phospholipase (cPL) A2, brain-derived neurotrophic factor (BDNF) and its receptor, and PUFA profile in the hippocampus were analyzed. IL-1β elevated biomarkers of microglial CD11b and...Continue Reading

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Citations

Oct 15, 2019·Frontiers in Pharmacology·Corinne JoffreSophie Layé
Apr 9, 2020·International Journal of Molecular Sciences·Thomas NuryAnne Vejux
Mar 27, 2020·Journal of Neuroinflammation·Smita Eknath Desale, Subashchandrabose Chinnathambi
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Jul 2, 2019·Therapeutic Advances in Psychopharmacology·Arne Reimers, Hanna Ljung
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Mar 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vincenzo LionettiTommaso Angelone
Apr 30, 2021·Expert Review of Neurotherapeutics·Marjan TalebiSaeed Samarghandian
Apr 19, 2018·Journal of Agricultural and Food Chemistry·Ah Young LeeEun Ju Cho

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