Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

Nature
Benoit ChassaingAndrew T Gewirtz

Abstract

The intestinal tract is inhabited by a large and diverse community of microbes collectively referred to as the gut microbiota. While the gut microbiota provides important benefits to its host, especially in metabolism and immune development, disturbance of the microbiota-host relationship is associated with numerous chronic inflammatory diseases, including inflammatory bowel disease and the group of obesity-associated diseases collectively referred to as metabolic syndrome. A primary means by which the intestine is protected from its microbiota is via multi-layered mucus structures that cover the intestinal surface, thereby allowing the vast majority of gut bacteria to be kept at a safe distance from epithelial cells that line the intestine. Thus, agents that disrupt mucus-bacterial interactions might have the potential to promote diseases associated with gut inflammation. Consequently, it has been hypothesized that emulsifiers, detergent-like molecules that are a ubiquitous component of processed foods and that can increase bacterial translocation across epithelia in vitro, might be promoting the increase in inflammatory bowel disease observed since the mid-twentieth century. Here we report that, in mice, relatively low concen...Continue Reading

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Citations

Feb 13, 2016·BMC Medicine·Laurent DolléBenoit Chassaing
Jan 31, 2016·Advanced Drug Delivery Reviews·Elena MorozJean-Christophe Leroux
Jul 17, 2015·Molecular Nutrition & Food Research·Patrice D Cani, Amandine Everard
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Jan 11, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Benoit Chassaing, Andrew T Gewirtz
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Methods Mentioned

BETA
Fluorescence
ELISA
antisense oligonucleotides
PCR
PCRs
electrophoresis
Confocal microscopy

Software Mentioned

Greengenes Prok _ MSA
Zen
R
FastTree
Prediction Analysis for Microarrays ( PAM )
GraphPad Prism
UCLUST
QIIME
Quantitative Insights Into Microbial Ecology ( QIIME

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