PMID: 7546218Sep 1, 1995Paper

Dietary energy restriction-induced modulation of protein kinase C zeta isozyme in the hamster pancreas

Molecular Carcinogenesis
S C NairDiane F Birt

Abstract

Dietary restriction in experimental animals enhances life span, delays disease, inhibits immunological perturbations, and ameliorates cancer. Protein kinase C (PKC) isozymes mediate signals generated by hormones, growth factors, and neurotransmitters for cell proliferation and differentiation. The results of our study showed that a C-terminally directed anti-PKC zeta antibody detected an 81-kDa band in the pancreases of control and energy-restricted hamsters. Syrian golden hamsters were fed energy-restricted diets formulated such that the hamsters received 90% (10% energy restriction (ER)), 80% (20% ER), or 60% (40% ER) of the total energy consumed by control hamsters, with the energy reduced proportionally from fat and carbohydrate. ER decreased PKC zeta isozyme levels by 40-75% in hamsters fed 10, 20, and 40% ER diets for 8 wk. PKC zeta isozyme expression was decreased by 75-80% in hamsters fed ER diets for 15 wk. Although ER caused significant decreases in PKC zeta isozyme levels compared with those of control hamsters at both time points, the relative differences in PKC zeta levels between the dietary ER groups (10, 20, and 40%) were small and not significant. A significant decrease in the body weights of ER animals compare...Continue Reading

References

Sep 1, 1992·Molecular and Cellular Biology·I DominguezJ Moscat
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Apr 16, 1990·Biochemical and Biophysical Research Communications·M HagiwaraH Hidaka
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Oct 1, 1987·The Journal of Nutrition·R L WalfordR Weindruch
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Aug 1, 1993·Molecular and Cellular Biology·M T Diaz-MecoJ Moscat

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