Dietary exposure to volatile and non-volatile N-nitrosamines from processed meat products in Denmark

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
S S HerrmannK Granby

Abstract

Recent epidemiological studies show a positive association between cancer incidence and high intake of processed meat. N-nitrosamines (NAs) in these products have been suggested as one potential causative factor. Most volatile NAs (VNAs) are classified as probable human carcinogens, whereas the carcinogenicity for the majority of the non-volatile NA (NVNA) remains to be elucidated. Danish adults (15-75 years) and children (4-6 years) consume 20 g and 16 g of processed meat per day (95th percentile), respectively. The consumption is primarily accounted for by sausages, salami, pork flank (spiced and boiled) and ham. This consumption results in an exposure to NVNA of 33 and 90 ng kg bw(-1) day(-1) for adults and children, respectively. The exposure to VNA is significantly lower amounting to 0.34 and 1.1 ng kg bw(-1) day(-1) for adults and children, respectively. Based on a BMDL10 of 29 µg kg bw(-1) day(-1) a MOE value ≥17,000 was derived for the exposure to NA known to be carcinogenic (VNA including NSAR), indicating an exposure of low concern. The exposure to the NVNA is substantially higher and if found to be of toxicological significance the exposure may be of concern.

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Citations

Dec 15, 2015·Environmental Research·José L Domingo, Martí Nadal
Apr 9, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sabrine SellimiMohamed Hajji
Jun 3, 2017·Environmental Toxicology·S A SheweitaH E Hassan
Feb 24, 2018·Journal of Toxicology and Environmental Health. Part a·Duck Soo LimByung-Mu Lee
Nov 9, 2018·Nucleic Acids Research·Katie A WilsonStacey D Wetmore
Aug 9, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Hyoung S Lee
Oct 22, 2017·Journal of Complementary & Integrative Medicine·Sabrine SellimiMoncef Nasri
Jun 14, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Karolina NowakEwa Jabłońska
Aug 18, 2020·Environmental Science and Pollution Research International·Malihe MoazeniAfshin Ebrahimi
Jun 15, 2017·EFSA Journal·UNKNOWN EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)Maged Younes
Mar 12, 2021·Journal of Pharmaceutical Sciences·David P ElderDavid J Snodin
Oct 17, 2020·Critical Reviews in Food Science and Nutrition·Moamen M ElmassryMohamed A Farag

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