Abstract
Inactivating mutations in APC are thought to be early, initiating events in colorectal carcinogenesis. To gain insight into the relationship between diet and inactivating APC mutations, we evaluated associations between dietary factors and the occurrence of these mutations in a Dutch case-control study of sporadic colorectal adenomas (278 cases; 414 polyp-free controls). Direct-sequencing was used to screen adenomas for mutations in the mutation cluster region of APC; truncating mutations were detected in 161 (58%) of the adenomas. Red meat consumption was significantly differently related to polyps with truncating APC mutation (APC(+) polyps) compared to polyps without truncating APC mutation (APC(-) polyps) (highest vs. lowest tertile, odds ratio [OR] = 0.5, 95% confidence interval [CI] = 0.3-1.0). High intake of red meat and fat seemed to increase the risk of APC(-) polyps only (APC(+) vs. controls: red meat, OR = 1.0, 95% CI = 0.6-1.6; fat, OR = 1.1, 95% CI = 0.6-1.9; APC(-) vs. controls: red meat, OR = 1.8, 95% CI = 1.0-3.1; fat, OR = 1.9, 95% CI = 1.0-3.7). Intake of carbohydrates was inversely associated with both polyp groups, most noticeably with APC(-) polyps. Most other evaluated dietary factors were not distinctivel...Continue Reading
References
Jul 1, 1992·Human Molecular Genetics·Y MiyoshiY Nakamura
Sep 17, 1992·Nature·S M PowellK W Kinzler
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·H KakiuchiM Nagao
Mar 21, 1997·Science·V KorinekH Clevers
Mar 21, 1997·Science·P J MorinK W Kinzler
Apr 1, 1997·The American Journal of Clinical Nutrition·W C WillettL H Kushi
Mar 17, 1997·International Journal of Cancer. Journal International Du Cancer·M O HiltunenJ Jänne
Jan 1, 1997·International Journal of Epidemiology·M C OckéD Kromhout
Jan 1, 1997·International Journal of Epidemiology·M C OckéD Kromhout
Apr 8, 1998·Current Opinion in Genetics & Development·K Willert, R Nusse
May 27, 1999·Genes & Development·R SmitsR Fodde
Jun 8, 1999·Journal of the National Cancer Institute·J D Potter
Sep 2, 1999·Nature Medicine·H LamlumI Tomlinson
Feb 5, 2000·Carcinogenesis·E KampmanP van't Veer
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J RowanI P Tomlinson
Sep 19, 2000·Genes, Chromosomes & Cancer·R SmitsR Fodde
Apr 20, 2001·Nutrition Reviews·T Norat, E Riboli
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·M L SlatteryW Samowitz
Mar 20, 2002·Nature Reviews. Cancer·R FoddeH Clevers
Jun 6, 2002·American Journal of Epidemiology·Stephanie A Smith-WarnerJohn D Potter
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gillian SmithC Roland Wolf
Feb 14, 2003·Carcinogenesis·Brenda DiergaardeEllen Kampman
Jul 2, 2003·Oncogene·Michael CrabtreeIan P M Tomlinson
Citations
Jul 20, 2007·Cancer Causes & Control : CCC·Matty P WeijenbergPiet A van den Brandt
Feb 6, 2013·Cancer Causes & Control : CCC·Dagfinn AuneTeresa Norat
Mar 16, 2012·Cancer Causes & Control : CCC·D AuneT Norat
Feb 21, 2004·Carcinogenesis·Margreet LüchtenborgAnton F P M de Goeij
Aug 29, 2013·Carcinogenesis·Anne M J GilsingMatty P Weijenberg
Dec 17, 2005·BMC Cancer·Margreet LüchtenborgAnton F P M de Goeij
Dec 11, 2013·Digestive Diseases and Sciences·Chang Geun LeeHyoun Woo Kang
Jun 1, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hui-Lee WongLawrence C Brody
Mar 14, 2007·International Journal of Cancer. Journal International Du Cancer·Aesun ShinWei Zheng
Feb 16, 2006·International Journal of Cancer. Journal International Du Cancer·Petra A WarkEllen Kampman
Aug 7, 2012·The Journal of Pathology·Laura J GayMark J Arends
May 4, 2012·International Journal of Cancer. Journal International Du Cancer·Xiaodong XuChuangang Fu
Jun 20, 2014·Alimentary Pharmacology & Therapeutics·J-Z ZhuY-M Li
Apr 20, 2012·The American Journal of Medicine·Shengjun WuDaiming Fan
Nov 13, 2013·Gastroenterology·Qiwen BenYaozong Yuan
Feb 5, 2013·Annals of Epidemiology·Bin XuYaozong Yuan
Jan 13, 2015·Gastroenterology·Mingyang SongAndrew T Chan
Jan 20, 2017·Journal of Digestive Diseases·Jing-Yuan FangUNKNOWN Chinese Society of Gastroenterology and the Committee on Gastrointestinal Tumors of the Chinese Society of Gastroenterology
May 13, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Farid E Ahmed
Nov 2, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Somruetai Shuangshoti, Chinachote Teerapakpinyo
Nov 5, 2017·Oncotarget·Xinyue ZhangRong He
Nov 23, 2006·The Journal of Nutrition·Stefan de VogelMatty P Weijenberg
Jun 15, 2021·Journal of Oncology·Li-Lianagzi GuoShao-Hui Tang