PMID: 6979045Mar 1, 1982Paper

Dietary fat affects immune response, production of antiviral factors, and immune complex disease in NZB/NZW mice

Proceedings of the National Academy of Sciences of the United States of America
J A LevyM B Gardner

Abstract

Autoimmune-prone (NZB x NZW)F1 (B/W) mice fed three nearly isocaloric diets with varied fat content showed a marked difference in their spontaneous development of immune complex disease and their immune response. Those animals received the diets high in either unsaturated or saturated fats had more severe immune complex nephritis and died earlier than mice on the low-fat diet. Endogenous production of the mouse xenotropic virus was unaffected by dietary fats, but the serum lipoproteins associated with antiviral activity were increased to levels as high as 1:600,000 in the B/W mice on the high-fat diets. These lipoproteins may be partially responsible for the decreased mitogenic response of spleen cells from mice fed the two high-fat diets. The mice receiving a diet high in saturated fats produced substantially higher titers of natural thymocytotoxic autoantibody, an IgM class of antibody, than did the mice maintained either on the high-unsaturated-fat or low-fat diet. In contrast, the mice receiving the diet high in unsaturated fats made significantly greater levels of antibodies to double-stranded DNA, an IgG, than did the mice kept on the two other diets. These results suggest that the type of fat in the diet could affect the...Continue Reading

References

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Citations

Sep 2, 1988·Biochimica Et Biophysica Acta·B C MillerG L Cottam
Jul 1, 1985·The Proceedings of the Nutrition Society·A D SmithJ Belin
Mar 30, 1999·The Proceedings of the Nutrition Society·L S Harbige
Aug 13, 2009·Physiological Genomics·Keith R ShockleyGary A Churchill
Jan 1, 1983·Progress in Lipid Research·M I Gurr
Jan 1, 1986·International Journal of Immunopharmacology·K L Erickson
Apr 1, 1985·Immunology Today·J HomsyJ A Levy
Apr 1, 1985·Immunology Today·A N Theofilopoulos
Sep 1, 1989·Clinical Immunology and Immunopathology·C GordonD Wofsy
Mar 1, 1996·The Proceedings of the Nutrition Society·P C Calder
Jul 8, 2000·The British Journal of Nutrition·M MoussaJ P Thouvenot
Dec 1, 1983·Arthritis and Rheumatism·W J Morrow, J A Levy
Jan 1, 1990·Annals of the New York Academy of Sciences·C L Keen, M E Gershwin
Mar 3, 1998·Nutrition Reviews·P C Calder
Mar 4, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M MoussaJ P Thouvenot

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