Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women.

Molecular and Cellular Biochemistry
Roberta PaulaOtávio Nóbrega

Abstract

Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fifty-two women (60 years or older) living in the outskirts of the Brazilian Federal District underwent clinical and laboratory assessments to characterize glycemic and lipidemic variables, and also to exclude confounding factors (smoking, drinking, hormone replacement, cognitive impairment, physical activity). Three-day food records were used to determine usual dietary intake, whereas genotypic evaluations were in accordance to established methodologies. Genotype frequencies were consistent with the Hardy-Weinberg equilibrium. Prior to adjustment, individuals carrying the epsilon2 allele showed higher serum levels of triglycerides (P<0.05) and VLDL (P<0.005) compared to epsilon4 carriers, whereas LDL levels were considerably elevated in epsilon4 compared to epsilon2 carriers. In the presence of high intake of total fat or a low ratio of polyunsaturated to saturated fatty acid, epsilon4 carriers lost protection agains...Continue Reading

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Citations

Jun 10, 2011·Clinics·Aparecido Pimentel FerreiraNancí Maria de França
Jan 28, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J A HubacekM Bobak
Jul 19, 2011·Archives of Gerontology and Geriatrics·Fernanda Cristina Jesus Colares-BentoOtávio Toledo Nobrega
Mar 16, 2012·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Clayton F MoraesOtávio T Nóbrega
Oct 15, 2013·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Juliana Lima QuintasOtávio Toledo Nóbrega
Mar 5, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E S AlvesO T Nóbrega

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