Dietary fat and risk of coronary heart disease: possible effect modification by gender and age

American Journal of Epidemiology
Marianne U JakobsenBerit L Heitmann

Abstract

In a 16-year follow-up study (ending in 1998) of 3,686 Danish men and women aged 30-71 years at recruitment, the association between energy intake from dietary fat and the risk of coronary heart disease was evaluated while assessing the possible modifying role of gender and age. In the models used, total energy and protein intake were fixed. Differences in intake of energy from fat thus reflected complementary differences in intake of energy from carbohydrates. A 5% higher level of energy from saturated fat intake was associated with a 36% greater risk of coronary heart disease among women (hazard ratio (HR) = 1.36, 95% confidence interval (CI): 0.98, 1.88). No overall association between saturated fat and coronary heart disease was found among men. However, age-dependent analyses showed that saturated fat was positively associated with coronary heart disease among the younger men (HR = 1.29, 95% CI: 0.87, 1.91) and the younger women (HR = 2.68, 95% CI: 1.40, 5.12) but not among the older men (HR = 0.94, 95% CI: 0.70, 1.28) and the older women (HR = 1.22, 95% CI: 0.86, 1.71). Polyunsaturated fat was inversely associated with coronary heart disease among women and men, although not significantly. In conclusion, the present study...Continue Reading

References

Sep 1, 1979·Circulation·D B Zilversmit
Nov 19, 1977·British Medical Journal·J N MorrisD G Clayton
Mar 28, 1985·The New England Journal of Medicine·L H KushiR Mulcahy
May 1, 1984·American Journal of Epidemiology·D Kromhout, C de Lezenne Coulander
Aug 1, 1980·The American Journal of Clinical Nutrition·M R Garcia-PalmieriM Rodriguez
Jan 8, 1981·The New England Journal of Medicine·R B ShekelleW J Raynor
Jun 15, 1993·American Journal of Epidemiology·V KipnisS Wacholder
Mar 1, 1993·The British Journal of Nutrition·A M FehilyP C Elwood
Jul 13, 1996·BMJ : British Medical Journal·A AscherioW C Willett
Nov 20, 1997·The New England Journal of Medicine·F B HuW C Willett
Sep 9, 1999·The American Journal of Clinical Nutrition·J H ChristensenE B Schmidt
Jul 18, 2002·European Journal of Clinical Nutrition·D R Boniface, M E Tefft

❮ Previous
Next ❯

Citations

Aug 17, 2010·Current Atherosclerosis Reports·Patty W Siri-TarinoRonald M Krauss
Aug 6, 2011·The British Journal of Nutrition·Janette de GoedeW M Monique Verschuren
Dec 14, 2007·International Journal of Epidemiology·Marianne U JakobsenBerit L Heitmann
Oct 12, 2010·Current Opinion in Lipidology·Marianne U Jakobsen, Kim Overvad
Dec 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Suely Godoy Agostinho GimenoUNKNOWN Japanese-Brazilian Diabetes Study Group
Jan 22, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Feb 13, 2009·The American Journal of Clinical Nutrition·Marianne U JakobsenAlberto Ascherio
Jan 15, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Mar 27, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D K HoustonUNKNOWN Health ABC Study
Mar 25, 2009·Maturitas·Tiny HoekstraYvonne T van der Schouw
Mar 4, 2008·American Journal of Preventive Medicine·Paul R MarantzMichael H Alderman
Mar 11, 2008·Progress in Lipid Research·Arja ErkkiläDavid E Laaksonen
Jul 4, 2007·Journal of Nutrition Education and Behavior·Patricia Markham RisicaUsree Kirtania
Feb 16, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Pfeuffer, J Schrezenmeir
Dec 3, 2005·Journal of the American Dietetic Association·Sébastien CzernichowSerge Hercberg
May 28, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Asim K Duttaroy
Mar 1, 2005·The Psychiatric Clinics of North America·Angela P Makris, Gary D Foster
Aug 20, 2005·Biochimica Et Biophysica Acta·Bernd W Koenig, Klaus Gawrisch
Nov 11, 2015·BMC Women's Health·Katerina M De VitoGraham A Colditz
Mar 24, 2006·Biological Research for Nursing·Amaia IrazustaJavier Gil
Feb 17, 2006·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Barbara Mary MurphyAlan James Goble
May 8, 2015·The American Journal of Clinical Nutrition·Lauren C BlekkenhorstJoshua R Lewis
Oct 3, 2014·Lipids in Health and Disease·Lukas Schwingshackl, Georg Hoffmann
Jul 10, 2010·Chemical Society Reviews·Fereidoon Shahidi, Ying Zhong
Sep 20, 2017·Critical Reviews in Food Science and Nutrition·Kumar GanesanBaojun Xu
Aug 26, 2011·The American Journal of Clinical Nutrition·Mia Sadowa VedtofteBerit L Heitmann
Oct 1, 2019·Epidemiology·Keewan KimSunni L Mumford
Oct 7, 2006·The American Journal of Clinical Nutrition·Jiaqiong XuElisa T Lee
Nov 27, 2009·The American Journal of Clinical Nutrition·J Edward HunterPenny M Kris-Etherton
Sep 1, 2018·European Journal of Nutrition·Linda E T VissersIvonne Sluijs
Aug 9, 2007·Arquivos brasileiros de endocrinologia e metabologia·Marselle R BevilacquaSandra R G Ferreira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.