PMID: 7931700Oct 1, 1994Paper

Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet

The Journal of Nutrition
K Eder, M Kirchgessner


Previous studies showed that zinc deficiency influences the fatty acid composition of rat tissues, but the influence of dietary fat on the effects of zinc deficiency was not considered at that time. The present study was therefore conducted to investigate the effect of zinc deficiency on lipid concentrations in the liver and on fatty acid composition of liver phospholipids in rats fed diets containing coconut oil or fish oil, using a bifactorial experimental design. To ensure an adequate food intake all rats were force-fed. The zinc-deficient rats fed the coconut oil diet developed fatty livers, whereas zinc-deficient animals fed the fish oil diet did not. The zinc-deficient rats in both dietary fat groups had lower levels of linoleic acid, arachidonic acid and total (n-6) fatty acids in the liver phospholipids, especially in the phosphatidylcholine, but greater concentrations of (n-3) fatty acids compared with zinc-adequate controls. We conjecture that zinc deficiency influences incorporation of polyunsaturated fatty acids into phosphatidylcholine. The lower levels of arachidonic acid are replaced in the zinc-deficient animals fed a coconut oil diet by docosapentaenoic and docosahexaenoic acids and in the zinc-deficient animal...Continue Reading


Aug 1, 1996·Biological Trace Element Research·K Eder, M Kirchgessner
Jun 14, 2017·Journal of Animal Physiology and Animal Nutrition·J O ZeitzK Eder
Aug 21, 2004·Biological Chemistry·Hannelore Daniel, Heike tom Dieck
Jun 8, 2012·Journal of Animal Physiology and Animal Nutrition·E Weigand, C Boesch-Saadatmandi
Oct 2, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·K EderB M Ross
May 1, 2018·Journal of Animal Physiology and Animal Nutrition·J O ZeitzK Eder
Jan 5, 2011·Journal of Animal Physiology and Animal Nutrition·E Weigand
Jan 22, 2008·Biological Trace Element Research·Takafumi Norii
Jun 3, 2021·International Journal of Molecular Sciences·Magdalena J M MarschallKlaus Eder

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