Dietary fat ingestion activates β-endorphin neurons in the hypothalamus

FEBS Letters
Shigenobu MatsumuraTohru Fushiki

Abstract

The opioid system regulates food choice, consumption, and reinforcement processes, especially for palatable meals such as fatty food. β-Endorphin is known as an endogenous opioid peptide produced in neurons of the hypothalamus. In this study, we found that Intralipid (fat emulsion) ingestion increased c-fos expression in β-endorphin neurons. However, intragastric infusion of Intralipid only slightly increased c-fos expression 2h after infusion. Further, dissection of glossopharyngeal nerve, innervating posterior tongue taste buds, partially but significantly decreased the Intralipid-induced c-fos expression. These results indicate that mainly the orosensory stimulation from fat may activate β-endorphin neurons, thereby promoting β-endorphin release.

References

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Mar 24, 2007·Biomedical Research·Shigenobu MatsumuraTohru Fushiki
Mar 20, 2009·Life Sciences·Takafumi MizushigeTohru Fushiki
Jun 6, 2009·Cell Metabolism·Lihong HuoChristian Bjørbaek

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Citations

Oct 16, 2013·Peptides·Richard J Bodnar
Mar 4, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuo NakamotoShogo Tokuyama
Jun 12, 2013·Bioscience, Biotechnology, and Biochemistry·Kumiko NakanoTohru Fushiki
Aug 1, 2015·Journal of Nutritional Science and Vitaminology·Kazuhiro SakamotoTohru Fushiki
Dec 18, 2014·Bioscience, Biotechnology, and Biochemistry·Kazuhiro SakamotoTohru Fushiki
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Tohru Fushiki
Sep 21, 2016·The Journal of Medical Investigation : JMI·Hiroshi TatanoYutaka Taketani

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