Dietary Fat Modifies the Effects of FTO Genotype on Changes in Insulin Sensitivity

The Journal of Nutrition
Yan ZhengLu Qi

Abstract

The common variants in the fat mass and obesity-associated (FTO) gene have been associated with obesity and insulin resistance. Recently, studies also linked FTO variants with macronutrient intakes. We aimed to investigate whether diet interventions varying in macronutrients modified the effects of FTO genotypes on changes in insulin resistance. We genotyped FTO variants rs1558902 and rs9939609 and measured insulin resistance in fasting plasma samples at baseline and at 6-mo and 2-y visits in 743 overweight or obese adults (aged 30-70 y, 60% women) from a randomized weight-loss dietary interventional trial, the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. We assessed interactions between FTO variants and intakes of dietary fat and protein in relation to change in body weight and insulin resistance using generalized estimating equation models. We found significant interactions between rs1558902 and dietary fat on changes in homeostasis model assessment of insulin resistance (HOMA-IR) and insulin (P = 0.003 and 0.004, respectively). Each risk allele (A) of rs1558902 showed a trend to be related to a 0.05-unit less reduction in both log(insulin) and log(HOMA-IR) among the participants assigned to low-f...Continue Reading

Associated Clinical Trials

References

Sep 17, 2002·The American Journal of Cardiology·Barry J Goldstein
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George StratigopoulosRudolph L Leibel
Apr 2, 2008·Journal of Human Genetics·Kikuko HottaYusuke Nakamura
Sep 17, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J A JacobssonH B Schiöth
Feb 28, 2009·The New England Journal of Medicine·Frank M SacksDonald A Williamson
Aug 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K GrauT I A Sørensen
Oct 6, 2009·Journal of the American Pharmacists Association : JAPhA·R Keith Campbell
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Feb 8, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·S D ReesT H Jafar
Feb 2, 2013·Human Molecular Genetics·Audrey Y ChuUNKNOWN DietGen Consortium
May 3, 2013·The American Journal of Clinical Nutrition·Toshiko TanakaJennifer A Nettleton

❮ Previous
Next ❯

Citations

Aug 16, 2016·Endocrinology and Metabolism Clinics of North America·George A Bray, Patty W Siri-Tarino
Aug 16, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·I LabayenL A Moreno
Apr 8, 2017·International Journal of Molecular Sciences·Yoriko Heianza, Lu Qi
Mar 9, 2018·Endocrine Reviews·George A BrayThomas H Inge
Jul 28, 2020·International Journal of Obesity Supplements·Luigi BarreaUNKNOWN Obesity Programs of nutrition, Education, Research and Assessment (OPERA) Group
Aug 28, 2020·Lipids in Health and Disease·Mahsa MehrdadMohammad Hassan Eftekhari
Nov 11, 2018·Frontiers of Medicine·Tiange WangGuang Ning
Mar 7, 2020·The American Journal of Clinical Nutrition·Kenneth WestermanJosé M Ordovás
Oct 13, 2020·Frontiers in Bioengineering and Biotechnology·Yajie GuoQingjiao Li
Feb 26, 2021·International Journal of Food Sciences and Nutrition·Golnoosh GoodarziParvin Mirmiran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.