Dietary fatty acid intake is associated with paraoxonase 1 activity in a cohort-based analysis of 1,548 subjects

Lipids in Health and Disease
Daniel S KimGail P Jarvik

Abstract

Paraoxonase 1 (PON1) is a cardioprotective, HDL-associated glycoprotein enzyme with broad substrate specificity. Our previous work found associations between dietary cholesterol and vitamin C with PON1 activity. The goal of this study was to determine the effect of specific dietary fatty acid (DFA) intake on PON1 activity. 1,548 participants with paraoxonase activity measures completed the Harvard Standardized Food Frequency Questionnaire to determine their daily nutrient intake over the past year. Eight saturated, 3 monounsaturated, and 6 polyunsaturated DFAs were measured by the questionnaire. To reduce the number of observations tested, only specific fatty acids that were not highly correlated (r < 0.8) with other DFAs or that were representative of other DFAs through high correlation within each respective group (saturated, monounsaturated, or polyunsaturated) were retained for analysis. Six specific DFA intakes - myristic acid (14 carbon atoms, no double bonds - 14:0), oleic acid (18:1), gadoleic acid (20:1), α-linolenic acid (18:3), arachidonic acid (20:4), and eicosapentaenoic acid (20:5) - were carried forward to stepwise linear regression, which evaluated the effect of each specific DFA on covariate-adjusted PON1 enzym...Continue Reading

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Citations

Sep 30, 2014·Nutrition & Metabolism·Daniel Seung KimGail P Jarvik
Mar 25, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·A GugliucciJ D Kark
Nov 25, 2017·European Journal of Clinical Investigation·Lynnda J N van Tienhoven-WindRobin P F Dullaart
Jun 27, 2014·Journal of the American Heart Association·Daniel Seung KimGail P Jarvik
Dec 29, 2018·Current Neuropharmacology·Estefania Gastaldello MoreiraMichael Maes
May 1, 2019·Archives of Endocrinology and Metabolism·Mauren Castro RittaAugusto Schneider
Apr 13, 2021·Archives of Endocrinology and Metabolism·Aline LongoRenata Torres Abib Bertacco
Nov 12, 2021·Archives of Endocrinology and Metabolism·Bianka Machado ZaniniAugusto Schneider

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