Dietary fatty acids and peripheral artery disease in adults.

Atherosclerosis
Asghar Z NaqviKenneth J Mukamal

Abstract

Peripheral artery disease (PAD) is a debilitating condition involving atherosclerosis. Although saturated, monounsaturated and polyunsaturated fatty acids have strong associations with atherosclerosis, it is unclear if diets high in these fatty acids affect PAD. We studied 6352 adults aged 40 years and older who participated in the U.S. National Health and Nutrition Examination Survey between 1999 and 2004. Ankle brachial index (ABI) was assessed by standardized blood pressure measurements, and we defined PAD as an ABI<0.9. Fatty acid intake was assessed by validated 24-h dietary recall. We used multivariable linear and logistic regression to estimate associations between intakes of dietary saturated fatty acids (SFAs), monounsaturated fatty acids (MFAs), marine omega-3 fatty acids (N-3), linolenic acid (LNA), and omega-6 fatty acids (N-6) and ABI/PAD. The prevalence and 95% confidence interval (CI) of PAD was 5.2% (95% CI 4.6-5.8). There were no associations between ABI and intakes of marine N-3 (p=0.83) or N-6 (p=0.19) in adjusted models. In contrast, LNA was associated with higher ABI (p=0.04) and SFA tended to be associated with lower ABI (p=0.06) in adjusted models. In addition, higher SFA was associated with a higher prev...Continue Reading

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Citations

Feb 5, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Miguel Ruiz-Canela, Miguel A Martínez-González
May 18, 2016·Current Treatment Options in Cardiovascular Medicine·T Raymond FoleyEhrin J Armstrong
Jan 23, 2014·JAMA : the Journal of the American Medical Association·Miguel Ruiz-CanelaMiguel A Martínez-González
Dec 8, 2016·The Journal of Nutrition, Health & Aging·M L RedmondT C Collins
Apr 3, 2020·Circulation Research·Xiaochao WeiClay F Semenkovich
Oct 26, 2018·Cardiovascular Diabetology·Mathilde NativelKamel Mohammedi
Jul 2, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Josiemer MatteiRobert C Kaplan

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