Dietary fatty acids differentially modulate messenger RNA abundance of low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and microsomal triglyceride transfer protein in Golden-Syrian hamsters.

Metabolism: Clinical and Experimental
Suzanne E Dorfman, Alice H Lichtenstein

Abstract

Dietary fatty acids modulate plasma and intracellular cholesterol concentrations. Circulating non-high-density lipoprotein cholesterol (nHDL-C) concentration is determined by rates of hepatic very low-density lipoprotein assembly and secretion, and clearance of subsequent metabolic products. The effect of dietary fat (butter, traditional margarine, soybean oil, and canola oil) was assessed with respect to plasma lipids, hepatic lipid composition, and messenger RNA (mRNA) abundance of low-density lipoprotein (LDL) receptor, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, sterol regulatory element-binding protein (SREBP) 2, and microsomal triglyceride transfer protein (MTP) in the Golden-Syrian hamster (Charles River Laboratories, Wilmington, MA). Hamsters were fed with a nonpurified diet (6.25 fat g/100 g) with 0.1 g cholesterol/100 g (control diet) or control diet with an additional 10 g experimental fat/100 g for 12 weeks. Hamsters fed with the control diet, unsaturated fats (canola and soybean oils), and margarine, relative to butter, had significantly lower total cholesterol and nHDL-C and triglyceride concentrations. Additional dietary fat, regardless of fatty acid profile, resulted in higher hepatic cholesterol ...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C M DaumerieJ M Dietschy
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ChenR N Redinger
Oct 25, 1996·The Journal of Biological Chemistry·R SatoM Maeda
Jan 1, 1996·Progress in Lipid Research·P Khosla, K Sundram
Apr 4, 1998·The American Journal of Cardiology·R M Krauss
Jul 3, 1998·Biochemical Society Transactions·J S KendrickJ A Higgins
Sep 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J WilkinsonD E Bowyer
Jun 24, 1999·The New England Journal of Medicine·A H LichtensteinE J Schaefer
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·T P CarrC L Schneider
May 22, 2001·Science·J L Goldstein, M S Brown
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Mar 14, 2002·Current Opinion in Lipidology·Donald B Jump
Nov 28, 2002·JAMA : the Journal of the American Medical Association·Frank B Hu, Walter C Willett
Aug 26, 2003·The American Journal of Clinical Nutrition·Jean-François MaugerBenoît Lamarche
Mar 18, 2004·Journal of Lipid Research·Jean-Charles HoguePatrick Couture
Apr 21, 2004·Experimental Biology and Medicine·Gene C Ness, Karen R Gertz
Mar 1, 2005·The Journal of Nutrition·Suzanne E DorfmanAlice H Lichtenstein

❮ Previous
Next ❯

Citations

Dec 15, 2010·Nutrition & Metabolism·Alice DillardAlice H Lichtenstein
Jul 4, 2012·The Journal of Nutritional Biochemistry·Ana Maria LottenbergEdna Regina Nakandakare
Jul 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Budhaditya MazumdarRanjit Ray
Jan 25, 2007·Journal of Biochemistry and Molecular Biology·Man Jeong PaikGwang Lee
Jan 25, 2007·Journal of Biochemistry and Molecular Biology·Hiroaki NagaiHidenori Ichijo
Sep 27, 2014·Animal : an International Journal of Animal Bioscience·O R Machado NetoM M Ladeira
Oct 16, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mark J McVeyRekha Mehta
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kanta ChechiSukhinder K Cheema
May 31, 2013·The American Journal of Clinical Nutrition·André J TremblayPatrick Couture

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.