Dietary fiber enhances a tumor suppressor signaling pathway in the gut.

Annals of Surgery
Khoa A NguyenTien C Ko

Abstract

To determine whether sodium butyrate (NaB), a major short-chain fatty acid produced in the human gut by bacterial fermentation of dietary fiber, enhances transforming growth factor (TGF)-beta signaling and potentiates its tumor suppressor activity in the gut. The molecular mechanisms by which dietary fiber decreases the risk of colon cancers are poorly characterized. TGF-beta is an important tumor suppressor in the gut and has many similar biologic activities as NaB. Therefore, we hypothesized that the chemo-preventive effects of NaB are mediated in part by enhancing TGF-beta signaling and its tumor suppressor function in the gut. The effects of NaB on Smad3 expression in rat intestinal epithelial (RIE-1) cells and 6 human colon cancer cell lines were examined. The effects of NaB on TGF-beta-induced Smad3 phosphorylation and plasminogen activator inhibitor-1 (PAI-1) and cyclooxygenase-2 (COX-2) gene expression were also examined in RIE-1 cells. Finally, the effects of NaB and TGF-beta on anchorage-independent growth were examined in Akt-transformed RIE-1 cells. NaB induced Smad3 in RIE-1 cells and in 4 human colon cancer cell lines. NaB enhanced TGF-beta-induced Smad3 phosphorylation and potentiated TGF-beta-induced PAI-1 expre...Continue Reading

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Citations

Mar 5, 2009·Cancer Prevention Research·Young S KimJohn A Milner
Apr 2, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yanna CaoTien C Ko
Sep 14, 2011·International Journal of Cell Biology·Stephen P HigginsPaul J Higgins
Feb 23, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xuxia GaoTien C Ko
Aug 21, 2015·Digestive Diseases and Sciences·Vincent K DikPeter D Siersema
Apr 19, 2011·The Journal of Nutritional Biochemistry·Hadas ShermanOren Froy
Oct 2, 2007·Current Problems in Cancer·Russell P Kruzelock, William Short
Apr 22, 2010·Journal of the National Cancer Institute·Christina C DahmSheila A Rodwell Bingham
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Dec 14, 2011·Chemistry & Biodiversity·Cecilia Beatriz Peña-ValdiviaMaritza H López

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